N6AMT1

Entrez Summary: N/A
UniProt Summary: Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:21193388}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.0125μM R03 exp97	-2.74
GSK461364A 0.005μM R03 exp125	-2.52
BI-2536 0.0042μM R03 exp95	-2.48
CVT-10216 0.1μM R06 exp278	-2.41
Heregulin-B 44ng/ml R08 exp486	-2.12
Vemurafenib 6.6μM R02 exp89	-2.06
Sucrose 20000μM R06 exp298	-1.87
UM131593 0.1μM R01 exp58	-1.81
Senexin-A 25μM R07 exp400	-1.73
CB-5083 0.4μM R08 exp468	1.71
Cytochalasin-B 5μM R07 exp349	1.77
Trientine 500μM R08 exp534	1.83
Aphidicolin 0.4μM R08 exp440	1.85
Vinblastine 0.015μM R05 exp208	1.88
THZ1 0.06μM R08 exp531	1.89
Vinblastine 0.2μM R03 exp108	1.89
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.92
LY2090314 0.003μM R08 exp500 no dilution day6	1.94
Salinomycin 3.5μM R08 exp521	1.95
Dorsomorphin 5μM R07 exp357	1.98
Calcium Ionophore 0.4μM R07 exp342	2.05
Genistein 15μM R07 exp360	2.09
Mitomycin-C 0.06μM R08 exp503	2.18
Lead acetate 2000μM R08 exp498 no dilution day6	2.22
MLN-4924 0.2μM R00 exp21	2.22
Thimerosal 0.85μM R08 exp529	2.26
TIC10 10μM R08 exp532	2.27
Lead acetate 2000μM R08 exp497	2.28
Hinokiflavone 12μM R08 exp487	2.32
Pyridostatin 4μM R05 exp240	2.35
CI-1040 9.5μM R08 exp472	2.36
Tozasertib 0.1μM R07 exp414	2.45
42°C R08 exp539	2.52
CR131-b 0.005μM R08 exp474	2.59
Tanespimycin 14μM R08 exp527	2.6
PU-H71 1μM R08 exp515	2.92
Trimetrexate 0.03μM R08 exp535	3.2
Milciclib 2μM R08 exp502	3.3
Thapsigargin 0.005μM R07 exp407	3.44
Latrunculin-B 10μM R07 exp374	3.62

Global Fraction of Cell Lines Where Essential: 81/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	2/28
bone	3/26
breast	1/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	4/20
lung	10/75
lymphocyte	3/16
ovary	2/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	3/15
prostate	0/1
skin	5/24
soft tissue	0/9
thyroid	1/2
upper aerodigestive	5/22
urinary tract	6/29
uterus	0/5

Expression Distribution

eRF1 methyltransferase complex
protein-glutamine N-methyltransferase activity
arsonoacetate metabolic process
DNA methylation on adenine
site-specific DNA-methyltransferase (adenine-specific) activity
methylarsonite methyltransferase activity
peptidyl-glutamine methylation
protein methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
toxin metabolic process
DNA alkylation
DNA methylation
secondary metabolic process
DNA methylation or demethylation
DNA modification
translational termination
xenobiotic metabolic process
protein alkylation
protein methylation
cellular protein complex disassembly
positive regulation of cell growth
cellular response to xenobiotic stimulus
nucleic acid binding
protein-containing complex disassembly
macromolecule methylation
positive regulation of growth
response to xenobiotic stimulus
methylation
translation
cellular component disassembly
peptide biosynthetic process
regulation of cell growth
amide biosynthetic process
peptide metabolic process
monocarboxylic acid metabolic process
protein-containing complex
regulation of growth
DNA metabolic process
cellular amide metabolic process
carboxylic acid metabolic process