CD2BP2

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 16/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution

spliceosomal tri-snRNP complex assembly
U5 snRNP
ribonucleoprotein complex binding
U4/U6 x U5 tri-snRNP complex
spliceosomal snRNP assembly
negative regulation of phosphatase activity
negative regulation of dephosphorylation
fibrillar center
regulation of phosphatase activity
regulation of dephosphorylation
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
negative regulation of hydrolase activity
ribonucleoprotein complex biogenesis
mRNA processing
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
mRNA metabolic process
negative regulation of catalytic activity
cellular protein-containing complex assembly
RNA processing
negative regulation of molecular function
regulation of hydrolase activity
protein-containing complex assembly
RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
protein-containing complex subunit organization
gene expression