CD2BP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CD2BP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD2BP2
  * **<color #00a2e8>Official Name</color>**: CD2 cytoplasmic tail binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10421|10421]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95400|O95400]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD2BP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD2BP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GYF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal tri-snRNP complex assembly|
|U5 snRNP|
|ribonucleoprotein complex binding|
|U4/U6 x U5 tri-snRNP complex|
|spliceosomal snRNP assembly|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|fibrillar center|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|mRNA metabolic process|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|RNA processing|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|protein-containing complex assembly|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.45|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.83|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.8|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.79|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.78|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.75|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.72|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.7|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.81|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.98|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tut1|TUT1]]|0.598|
|[[:human genes:a:aar2|AAR2]]|0.492|
|[[:human genes:n:ncdn|NCDN]]|0.491|
|[[:human genes:d:dph1|DPH1]]|0.452|
|[[:human genes:n:n6amt1|N6AMT1]]|0.441|
|[[:human genes:w:wdr77|WDR77]]|0.416|
|[[:human genes:p:ptbp1|PTBP1]]|0.41|
|[[:human genes:c:ctu1|CTU1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4747
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD2BP2 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>