SMEK1

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-3.31
MK-1775 0.32μM R02 exp75	-3.01
Taxol 0.004μM R03 exp103	-2.57
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.27
Vinblastine 0.002μM R01 exp60	-2.24
3-Bromopyruvate 7μM R04 exp175	-2.17
BI-2536 0.0042μM R03 exp95	-2.15
Cadmium 60μM R08 exp462	-2.04
Epothilone-B 0.0015μM R05 exp231	-2
5-Fluorouracil 2μM R00 exp1	-1.89
Erlotinib 10μM R05 exp216	-1.87
MLN-4924 0.2μM R00 exp21	-1.81
VER-155008 3.9μM R06 exp301	1.71
Fluvastatin 2.2μM R06 exp282	2.05
SNS-032 15μM R08 exp443	2.07
RO-3307 4.7μM R02 exp80	2.3
Rotenone 20μM R00 exp34	2.34
Dorsomorphin 5μM R07 exp357	2.44
I-BRD9 4μM R07 exp365	2.46
Arsenate 40μM R06 exp264	2.73
Milciclib 2μM R08 exp502	3.41
GSK626616 14μM R08 exp485	4.35

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution