KCTD5
Gene Information
- Official Symbol: KCTD5
- Official Name: potassium channel tetramerization domain containing 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 54442
- UniProt: Q9NXV2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
Pfam Domains GO Terms
Pfam Domains
| K tetra |
GO Terms
| cullin family protein binding |
| Cul3-RING ubiquitin ligase complex |
| protein-containing complex binding |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| protein homooligomerization |
| proteasomal protein catabolic process |
| protein complex oligomerization |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| viral process |
| symbiotic process |
| interspecies interaction between organisms |
| cellular macromolecule catabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| identical protein binding |
| proteolysis |
| protein-containing complex assembly |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PPP6C | 0.519 |
| LSM10 | 0.507 |
| SLC25A26 | 0.505 |
| BAK1 | 0.499 |
| LZTR1 | 0.485 |
| ROMO1 | 0.485 |
| SRP14 | 0.464 |
| ENY2 | 0.461 |
| NF1 | 0.458 |
| TRIAP1 | 0.45 |
| PLAA | 0.448 |
| RPIA | 0.445 |
| ALG1 | 0.443 |
| CASP9 | 0.442 |
| AASDHPPT | 0.441 |
| PMM2 | 0.439 |
| VDAC2 | 0.437 |
| MARCH5 | 0.436 |
| THG1L | 0.433 |
| DR1 | 0.432 |
| STAU1 | 0.426 |
| ADSL | 0.424 |
| THOC6 | 0.424 |
| PTPN6 | 0.423 |
| UHRF1 | 0.42 |
| DOHH | 0.42 |
| CYCS | 0.419 |
| NDUFAF4 | 0.419 |
| HARS | 0.418 |
| RPE | 0.418 |
| PELO | 0.418 |
| FH | 0.415 |
| PPP2R3C | 0.414 |
| HCCS | 0.414 |
| ATIC | 0.413 |
| CAMK2G | 0.411 |
| SMEK1 | 0.41 |
| UBA3 | 0.409 |
| FAF2 | 0.407 |
| SERF2 | 0.406 |
| UBE2M | 0.406 |
| ATP2B1 | 0.405 |
| PHF6 | 0.403 |
| APAF1 | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4558
- Expression level (log2 read counts): 5.36
Expression Distribution
KCTD5 Expression in NALM6 Cells: 5.36
