NDUFAF4

Entrez Summary: NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency. [provided by RefSeq, Oct 2009].
UniProt Summary: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. {ECO:0000269|PubMed:14871833, ECO:0000269|PubMed:17001319, ECO:0000269|PubMed:18179882}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dorsomorphin 5μM R07 exp357	1.7
AICAR 240μM R03 exp116	1.71
GSK461364A 0.1μM R03 exp126	1.71
Quercetin 20μM R08 exp517	1.74
Pimelic-diphenylamide-106 5μM R00 exp28	1.79
UM0125461 0.74μM R02 exp84	1.79
Actinomycin-D 0.001μM R00 exp3	1.81
Resveratrol 16μM R03 exp147	1.83
Azithromycin 100μM R08 exp452	1.98
NN-Dimethylsphingosine 2.5μM R08 exp508	1.98
ONC212 0.15μM R08 exp513	2.11
Hydroxyurea 100μM R07 exp329	2.38
Hinokiflavone 12μM R08 exp487	2.43
Artemisinin 50μM R08 exp450	2.5
42°C R08 exp539	2.69
HMS-I2 10μM R06 exp288	2.89
Oligomycin-A 2μM R00 exp25	3.07
Tanespimycin 14μM R08 exp527	3.09

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial respiratory chain complex assembly
mitochondrial membrane
calmodulin binding
mitochondrial inner membrane
mitochondrion organization
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization