TIMM21

Entrez Summary: N/A
UniProt Summary: Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. {ECO:0000269|PubMed:23260140}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TIM23 mitochondrial import inner membrane translocase complex
protein import into mitochondrial matrix
mitochondrial respiratory chain complex IV assembly
respiratory chain complex IV assembly
cytochrome complex assembly
protein transmembrane import into intracellular organelle
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
mitochondrial respiratory chain complex assembly
protein import
mitochondrial transport
protein targeting
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
molecular function
cellular protein-containing complex assembly
intracellular protein transport
transmembrane transport
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
protein-containing complex subunit organization