TIMM21 [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM21
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29090|29090]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVV7|Q9BVV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. {ECO:0000269|PubMed:23260140}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIM21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TIM23 mitochondrial import inner membrane translocase complex|
|protein import into mitochondrial matrix|
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|mitochondrial respiratory chain complex assembly|
|protein import|
|mitochondrial transport|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|molecular function|
|cellular protein-containing complex assembly|
|intracellular protein transport|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.58|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.22|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.07|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.87|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.79|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.78|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.81|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.88|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.96|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.99|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|5.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.475|
|[[:human genes:o:oma1|OMA1]]|0.472|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.452|
|[[:human genes:n:ndufb11|NDUFB11]]|0.441|
|[[:human genes:a:atp5sl|ATP5SL]]|0.432|
|[[:human genes:n:ndufa3|NDUFA3]]|0.428|
|[[:human genes:n:ndufb9|NDUFB9]]|0.428|
|[[:human genes:n:ndufa11|NDUFA11]]|0.424|
|[[:human genes:n:ndufb6|NDUFB6]]|0.42|
|[[:human genes:m:mrpl45|MRPL45]]|0.418|
|[[:human genes:t:tmem261|TMEM261]]|0.416|
|[[:human genes:n:ndufb5|NDUFB5]]|0.41|
|[[:human genes:n:ndufs7|NDUFS7]]|0.407|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.405|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.404|
|[[:human genes:n:ndufc2|NDUFC2]]|0.404|
|[[:human genes:g:gfm1|GFM1]]|0.402|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.401|
|[[:human genes:r:rpusd3|RPUSD3]]|0.401|
|[[:human genes:g:grsf1|GRSF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM21 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>