NDUFA10

Entrez Summary: The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.91
SGC2043 10μM R03 exp152	-1.88
IU1-47 25μM R04 exp182	-1.73
PT-1 25μM R07 exp392	2.02
Nutlin-3A 1.6μM R06 exp294	2.23
Mubritinib 0.2μM R02 exp65	2.28
Atovaquone 15μM R08 exp451	2.31
HMS-I2 10μM R06 exp288	2.31
Oligomycin-A 2μM R00 exp25	3.33

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial matrix
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
mitochondrion
phosphorylation
protein-containing complex assembly
protein-containing complex subunit organization