MCAT

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. {ECO:0000269|PubMed:12882974}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fatty acid synthase activity
[acyl-carrier-protein] S-malonyltransferase activity
fatty acid beta-oxidation
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
monocarboxylic acid catabolic process
fatty acid biosynthetic process
monocarboxylic acid biosynthetic process
cellular lipid catabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
mitochondrial matrix
small molecule catabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
mitochondrion
RNA binding
small molecule metabolic process
organic substance catabolic process
cellular catabolic process