AK3

Gene Information

Official Symbol: AK3
Official Name: adenylate kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 50808
UniProt: Q9UIJ7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
UniProt Summary: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000255|HAMAP-Rule:MF_03169, ECO:0000269|PubMed:11485571}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-839 10μM R05 exp224	-1.93
GW501516 25μM R06 exp285	-1.75
Senexin-A 25μM R07 exp400	1.71
CoCl2 18μM R07 exp346	1.73
HMS-I2 10μM R06 exp288	2.31
Bafilomycin-A1 0.009μM R08 exp454	2.5
Arsenic trioxide 60μM R08 exp449	2.66

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3282
Expression level (log2 read counts): 5.58

Expression Distribution

Gene	Correlation
NDUFA2	0.459
MCAT	0.45
GFM2	0.428
GTPBP10	0.419
MTO1	0.415
NDUFA3	0.405
NDUFAF7	0.402

ADK lid
ADK

ITP metabolic process
nucleoside triphosphate adenylate kinase activity
ADP biosynthetic process
purine nucleoside diphosphate biosynthetic process
ribonucleoside diphosphate biosynthetic process
purine ribonucleoside diphosphate biosynthetic process
nucleoside diphosphate biosynthetic process
adenylate kinase activity
UTP metabolic process
nucleoside monophosphate phosphorylation
AMP metabolic process
pyrimidine ribonucleoside triphosphate metabolic process
pyrimidine nucleoside triphosphate metabolic process
pyrimidine ribonucleotide metabolic process
GTP metabolic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
guanosine-containing compound metabolic process
ADP metabolic process
ribonucleoside monophosphate metabolic process
purine ribonucleoside triphosphate metabolic process
purine ribonucleoside metabolic process
purine nucleoside diphosphate metabolic process
pyrimidine nucleotide metabolic process
purine ribonucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
purine nucleoside metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process