GW501516 25μM R06 exp285 [The Human Chemical-Genetic Interaction Map Project]

PPARδ receptor agonist, increases metabolism, banned performance enhancer

Class / Subclass 1: Gene Regulation / Nuclear Receptor Ligand
Class / Subclass 2: Metabolism / Hormone Agonist

Compound References

PubChem Name: Endurobol
Synonyms: GW 1516; GSK-516
CAS #: 317318-70-0
PubChem CID: 9803963
IUPAC: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
INCHI Name: InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
INCHI Key: YDBLKRPLXZNVNB-UHFFFAOYSA-N
Molecular Weight: 453.5
Canonical SMILES: CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O
Isomeric SMILES: N/A
Molecular Formula: C21H18F3NO3S2

Compound Supplier

Supplier Name: Sigma-Aldrich
Catalog #: SML1491
Lot #: 1798

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H18F3NO3S2 454.0753; found 454.0758

Dose Response Curve

Platform ID: GW501516
Min: -11.0338; Max: 33.5004

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 06
Dose: 25µM
Days of incubation: 8
Doublings: 7.0
Numbers of reads: 8109612

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
1/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
KDSR	-3.47	<0.01
AURKB	-2.70	0.69
FARS2	-2.52	0.47
KRTAP10-3	-2.39	0.69
NME6	-2.26	0.47
C5orf15	-2.24	0.47
VPS25	-2.12	0.79
ZIC1	-2.12	0.69
HDAC4	-2.08	0.69
CIC	-2.06	0.69
GCLC	-2.02	0.69
TTC27	-2.00	0.69
UHRF1	-2.00	0.69
CBFB	-1.99	0.69
TCF12	-1.98	0.69
ALG5	-1.96	0.69
ERCC2	-1.96	0.77
SLC29A2	-1.94	0.69
C6orf136	-1.94	0.69
EPHA4	-1.92	0.69
MRPS18A	-1.92	0.69
TMEM106B	-1.91	0.69
STARD10	-1.91	0.69
RPL36A-HNRNPH2	-1.90	0.87
CCR9	-1.88	0.69
SART3	-1.87	0.79
TMC2	-1.87	0.77
CCNH	-1.87	0.69
IFNL2	-1.87	0.69
PCOLCE2	-1.86	0.69
SLC16A12	1.93	0.46
MRPS30	1.95	0.46
CCND3	1.96	0.89
PAFAH1B1	2.01	0.91
ARG2	2.01	0.42
BUB1	2.01	0.42
CDH5	2.01	0.46
FSIP2	2.03	0.46
POTED	2.04	0.42
RNASEH2A	2.09	0.51
RBBP8NL	2.11	0.42
DDX47	2.13	0.86
PPP6R1	2.15	0.42
DUSP6	2.15	0.41
SKIV2L2	2.17	0.75
OR4C6	2.17	0.41
DHX38	2.18	0.56
ZCCHC10	2.18	0.42
PCBP4	2.20	0.42
CDC6	2.21	0.42
PSMB8	2.21	0.41
POLD2	2.27	0.63
EIF3G	2.27	0.41
KMT2D	2.34	0.41
CLEC4M	2.36	0.41
KANSL1	2.36	0.41
PPP5C	2.51	0.35
CDT1	2.53	0.46
RPL37	2.55	0.62
KAT8	2.61	0.46

Last modified: 2026/01/15 21:36
by 127.0.0.1