PCBP4

Gene Information

Official Symbol: PCBP4
Official Name: poly(rC) binding protein 4
Aliases and Previous Symbols: N/A
Entrez ID: 57060
UniProt: P57723
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12270
Expression level (log2 read counts): 6.08

Expression Distribution

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction involved in mitotic DNA integrity checkpoint
signal transduction involved in mitotic DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
intracellular signal transduction involved in G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
mitotic G1 DNA damage checkpoint
G1 DNA damage checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in cell cycle checkpoint
mRNA 3-UTR binding
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
signal transduction in response to DNA damage
mitotic DNA integrity checkpoint
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
signal transduction by p53 class mediator
DNA damage checkpoint
DNA integrity checkpoint
regulation of G1/S transition of mitotic cell cycle
mitotic cell cycle checkpoint
regulation of cell cycle G1/S phase transition
regulation of mRNA stability
regulation of RNA stability
cell cycle checkpoint
regulation of mRNA catabolic process
negative regulation of mitotic cell cycle phase transition
negative regulation of cell cycle phase transition
positive regulation of cell cycle process
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of mRNA metabolic process
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition