KAT8
Gene Information
- Official Symbol: KAT8
- Official Name: lysine acetyltransferase 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 84148
- UniProt: Q9H7Z6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Tudor-knot |
| MOZ SAS |
GO Terms
| MSL complex |
| histone acetyltransferase activity (H4-K5 specific) |
| histone acetyltransferase activity (H4-K16 specific) |
| histone acetyltransferase activity (H4-K8 specific) |
| histone H4-K8 acetylation |
| histone H4-K5 acetylation |
| acetyltransferase activity |
| histone H4-K16 acetylation |
| histone acetyltransferase complex |
| MLL1 complex |
| histone acetyltransferase activity |
| histone H4 acetylation |
| methylated histone binding |
| kinetochore |
| nuclear matrix |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| histone binding |
| protein acetylation |
| protein acylation |
| myeloid cell differentiation |
| nuclear chromatin |
| peptidyl-lysine modification |
| regulation of autophagy |
| transcription factor binding |
| enzyme binding |
| histone modification |
| covalent chromatin modification |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| immune system development |
| chromatin organization |
| regulation of cellular catabolic process |
| peptidyl-amino acid modification |
| regulation of catabolic process |
| chromosome organization |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.04μM R03 exp98 | -1.86 |
| JQ1 0.8μM R08 exp435 | -1.82 |
| Actinomycin-D 0.001μM R00 exp3 | -1.72 |
| PF-06409577 20μM R07 exp389 | 1.71 |
| 35°C R06 exp302 | 1.89 |
| Nutlin-3A 1.6μM R06 exp294 | 1.97 |
| KU-0063794 3.8μM R02 exp71 | 2.03 |
| RO-3306 3 to 4μM on day4 R04 exp165 | 2.32 |
| GW501516 25μM R06 exp285 | 2.61 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 381/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 16/28 |
| blood | 12/28 |
| bone | 10/25 |
| breast | 19/33 |
| central nervous system | 33/56 |
| cervix | 3/4 |
| colorectal | 9/17 |
| esophagus | 3/13 |
| fibroblast | 0/1 |
| gastric | 6/15 |
| kidney | 10/21 |
| liver | 10/20 |
| lung | 44/75 |
| lymphocyte | 6/14 |
| ovary | 18/26 |
| pancreas | 12/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 7/15 |
| prostate | 1/1 |
| skin | 16/24 |
| soft tissue | 5/7 |
| thyroid | 0/2 |
| upper aerodigestive | 6/22 |
| urinary tract | 14/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 951
- Expression level (log2 read counts): 5.42
Expression Distribution
KAT8 Expression in NALM6 Cells: 5.42
