ZIC1

Entrez Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity). {ECO:0000250|UniProtKB:P46684}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GW501516 25μM R06 exp285	-2.12
All-trans-Retinoic-Acid 40μM R07 exp334	-1.84
Cidofovir 10μM R07 exp345	-1.83
KU-0063794 3.8μM R02 exp71	-1.81
Centrinone 0.5μM R07 exp343	-1.78
ML-792 0.2μM R08 exp505	-1.77
Geldanamycin 0.01μM R05 exp235	2.83

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adult walking behavior
walking behavior
positive regulation of protein import into nucleus
positive regulation of protein import
regulation of protein import into nucleus
regulation of protein import
positive regulation of nucleocytoplasmic transport
positive regulation of protein localization to nucleus
adult locomotory behavior
regulation of smoothened signaling pathway
inner ear morphogenesis
regulation of nucleocytoplasmic transport
spinal cord development
regulation of protein localization to nucleus
ear morphogenesis
adult behavior
positive regulation of intracellular protein transport
inner ear development
locomotory behavior
positive regulation of intracellular transport
ear development
regulation of intracellular protein transport
sensory organ morphogenesis
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of establishment of protein localization
RNA polymerase II proximal promoter sequence-specific DNA binding
regulation of cellular protein localization
sensory organ development
embryonic morphogenesis
behavior
DNA-binding transcription factor activity
regulation of protein transport
regulation of peptide transport