SLC29A2

Entrez Summary: N/A
UniProt Summary: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269|PubMed:9396714}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinate 1000μM R03 exp140	-2.15
GW501516 25μM R06 exp285	-1.94
Menadione 5μM R06 exp292	-1.94
HMS-I2 10μM R06 exp288	-1.88
Taxol 0.004μM R03 exp103	-1.74
UMK57 0.6μM R03 exp107	-1.74
Arsenate 40μM R06 exp264	-1.71
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.72
Chloroquine 32μM R08 exp470	1.74
Thioridazine 5μM R08 exp530	1.79
Nicotinamide 2000μM R01 exp50	1.87

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hypoxanthine transport
thymine transport
guanine transport
uridine transport
pyrimidine nucleoside transport
adenine transport
pyrimidine nucleobase transport
purine nucleobase transport
nucleoside transport
nucleoside transmembrane transport
nucleoside transmembrane transporter activity
nucleobase transport
neurotransmitter reuptake
neurotransmitter uptake
carbohydrate derivative transport
presynapse
neurotransmitter transport
basolateral plasma membrane
nuclear membrane
nucleobase-containing compound transport
regulation of neurotransmitter levels
import into cell
nucleolus
transmembrane transport
integral component of plasma membrane
establishment of localization in cell
nitrogen compound transport