MALSU1

Entrez Summary: N/A
UniProt Summary: May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. {ECO:0000269|PubMed:22238376}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitochondrial translation
negative regulation of ribosome biogenesis
ribosomal large subunit binding
regulation of ribosome biogenesis
regulation of mitochondrial translation
regulation of mitochondrial gene expression
mitochondrial large ribosomal subunit
ribosomal large subunit biogenesis
negative regulation of translation
negative regulation of cellular amide metabolic process
ribosome biogenesis
regulation of translation
regulation of cellular amide metabolic process
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
regulation of cellular component biogenesis
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
mitochondrion
negative regulation of cellular macromolecule biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression