FASTKD2

Gene Information

Official Symbol: FASTKD2
Official Name: FAST kinase domains 2
Aliases and Previous Symbols: N/A
Entrez ID: 22868
UniProt: Q9NYY8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008].
UniProt Summary: Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). {ECO:0000269|PubMed:25683715}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	1.7
Resveratrol 16μM R03 exp147	1.71
Dorsomorphin 5μM R07 exp357	1.76
Temozolomide 200μM R04 exp189	1.8
Thimerosal 0.85μM R08 exp529	1.8
Rifampicin 10μM R00 exp32	1.81
Tubacin 1.6μM R07 exp416	1.82
HMS-I2 5μM R06 exp287	1.84
Bafilomycin-A1 0.009μM R08 exp454	1.89
Vemurafenib 6.6μM R02 exp89	1.96
Hydroxyurea 100μM R07 exp329	2.01
Rapamycin 1μM R00 exp29	2.03
Genistein 15μM R07 exp360	2.08
Chloroquine 32μM R08 exp470	2.29
BML-284 0.09μM R08 exp460	2.38
UM0125461 0.74μM R02 exp84	2.83
Oligomycin-A 2μM R00 exp25	2.98
HMS-I2 10μM R06 exp288	2.99

Gene	Correlation
GRSF1	0.628
NDUFA11	0.607
ACAD9	0.603
MTO1	0.595
RMND1	0.581
MTIF2	0.581
METTL17	0.574
MTRF1L	0.572
RPUSD3	0.57
GTPBP10	0.563
NDUFAF7	0.563
NDUFAF3	0.559
NUBPL	0.557
NDUFB10	0.556
NDUFA1	0.555
NDUFAF5	0.554
LARS2	0.552
NDUFS2	0.55
NDUFB11	0.55
NDUFA2	0.548
NSUN4	0.547
PET117	0.547
PET112	0.545
PREPL	0.544
ERAL1	0.541
NDUFAF6	0.54
NDUFC1	0.54
DDX28	0.537
CHCHD1	0.536
NDUFA3	0.534
FTSJ2	0.533
COQ2	0.532
XPNPEP3	0.531
TFB1M	0.531
MCAT	0.529
MRPL45	0.528
HMGXB3	0.527
GFM2	0.526
SSBP1	0.524
CLPP	0.523
CARS2	0.521
COQ7	0.521
MPV17L2	0.52
MRPL1	0.518
SFXN4	0.517
TIMMDC1	0.515
MTERFD1	0.512
FOXRED1	0.512
NDUFB9	0.509
MRPS27	0.508
GTPBP6	0.507
NDUFS5	0.506
NDUFC2	0.503
MRPS21	0.502
PDE12	0.502
MALSU1	0.499
ATP5SL	0.499
MTG1	0.495
C12orf65	0.492
ECSIT	0.491
NARS2	0.49
GFM1	0.49
IBA57	0.487
QRSL1	0.486
MRPL22	0.479
NDUFB7	0.478
PTCD3	0.478
NDUFA8	0.476
NDUFAF1	0.475
MRPL4	0.472
NDUFB6	0.47
MTG2	0.469
NOA1	0.467
MCUR1	0.462
NSUN3	0.462
TRIT1	0.461
RNMTL1	0.461
NDUFA10	0.459
MRPS10	0.458
NDUFS8	0.457
RBFA	0.457
MRPL53	0.456
GTPBP8	0.456
CCDC90B	0.456
NDUFV1	0.454
NDUFV2	0.453
LRPPRC	0.453
NDUFAF4	0.452
MRPL21	0.452
RTN4IP1	0.452
COA3	0.451
WARS2	0.451
NDUFB2	0.449
ICT1	0.449
MRPS25	0.448
TIMM17A	0.447
NDUFB5	0.446
NDUFS3	0.443
TOMM7	0.441
POLRMT	0.44
COA6	0.44
NDUFA6	0.44
POLG2	0.44
EARS2	0.439
MRPL23	0.438
MRPS5	0.436
C1QBP	0.436
NDUFB4	0.436
AARS2	0.435
MRP63	0.435
AIFM1	0.434
MRPL28	0.433
MRPL43	0.433
MRPL44	0.433
TIMM8B	0.432
MRPS6	0.431
MRPS35	0.43
RPUSD4	0.429
PARS2	0.429
MRPL2	0.429
MRPL17	0.429
MRPL49	0.426
MRPL3	0.425
NDUFB8	0.425
MTERFD2	0.423
TARS2	0.422
TSFM	0.421
RNASEH1	0.419
MIPEP	0.418
COX18	0.418
MRPS18B	0.417
MRPS12	0.417
MRPL47	0.417
DAP3	0.416
MRPL12	0.416
TMEM261	0.416
MRPS16	0.414
MRPL13	0.413
WBSCR16	0.413
SELRC1	0.411
TRUB2	0.41
MARS2	0.408
MRPL48	0.407
MRPS34	0.407
MDH2	0.407
MRPS22	0.407
FASTKD5	0.406
HSD17B10	0.406
MRPL15	0.401
SLC30A9	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1329
Expression level (log2 read counts): 6.12

Expression Distribution

FAST 1
RAP
FAST 2

mitochondrial large ribosomal subunit assembly
mitochondrial ribosome assembly
ribonucleoprotein granule
positive regulation of mitochondrial translation
regulation of mitochondrial translation
regulation of mitochondrial gene expression
ribosomal large subunit assembly
rRNA binding
mitochondrial nucleoid
intercellular bridge
ribosome assembly
ribosomal large subunit biogenesis
positive regulation of translation
positive regulation of cellular amide metabolic process
cellular respiration
ribonucleoprotein complex assembly
energy derivation by oxidation of organic compounds
protein kinase activity
ribonucleoprotein complex subunit organization
ribosome biogenesis
regulation of translation
regulation of cellular amide metabolic process
generation of precursor metabolites and energy
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
organelle assembly
cellular protein-containing complex assembly
oxidation-reduction process
protein phosphorylation
mitochondrion
phosphorylation
RNA binding
protein-containing complex assembly
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process