MDH2

Entrez Summary: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ldh 1 C
Ldh 1 N

malate dehydrogenase (NADP+) activity
L-malate dehydrogenase activity
oxaloacetate metabolic process
malate metabolic process
tricarboxylic acid cycle
NADH metabolic process
gluconeogenesis
hexose biosynthetic process
monosaccharide biosynthetic process
protein self-association
aerobic respiration
dicarboxylic acid metabolic process
glucose metabolic process
internal protein amino acid acetylation
carbohydrate biosynthetic process
protein acetylation
hexose metabolic process
cellular respiration
protein acylation
monosaccharide metabolic process
energy derivation by oxidation of organic compounds
mitochondrial matrix
generation of precursor metabolites and energy
carbohydrate metabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
RNA binding
small molecule metabolic process
membrane