MCUR1

Entrez Summary: N/A
UniProt Summary: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846). {ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:26445506, ECO:0000269|PubMed:26976564, ECO:0000269|PubMed:27184846}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cycloheximide 0.2μM R00 exp15	1.7
Chlorpromazine 10μM R07 exp344	1.71
Tubacin 1.6μM R07 exp416	1.75
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.76
FK-506 30μM R07 exp359	1.76
IU1-C 25μM R04 exp183	1.84
Dynasore 7μM R08 exp436	1.85
CoCl2 18μM R07 exp346	1.92
MK-1775 0.32μM R02 exp75	1.96
Etoposide 0.1μM R05 exp198	2.05
Trametinib 10μM R02 exp83	2.07
Artemisinin 50μM R08 exp450	2.12
LJH685 50μM R08 exp433	2.17
Genistein 15μM R07 exp360	2.21
FTY720 3μM R08 exp483	2.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium import into the mitochondrion
positive regulation of mitochondrial calcium ion concentration
mitochondrial calcium ion transmembrane transport
mitochondrial calcium ion homeostasis
integral component of mitochondrial inner membrane
calcium ion import
cytosolic calcium ion transport
mitochondrial transmembrane transport
calcium ion transmembrane transport
mitochondrial transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
chemical homeostasis
mitochondrion
transmembrane transport
ion transport
homeostatic process