MPV17L2

Entrez Summary: N/A
UniProt Summary: Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607). {ECO:0000269|PubMed:24948607}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 0.1μM R05 exp198	1.7
BML-284 0.09μM R08 exp460	1.72
VER-155008 3.9μM R06 exp301	1.73
All-trans-Retinoic-Acid 40μM R07 exp334	1.75
LJH685 50μM R08 exp433	1.76
Isonicotinamide 500μM R03 exp129	1.77
Ribavirin 10 to 15μM on day4 R04 exp160	1.78
Pterostilbene 16μM R02 exp78	1.8
Ribavirin 10μM R01 exp52	1.8
A-395 10μM R05 exp218	1.81
Cycloheximide 0.2μM R00 exp15	1.81
Dynasore 7μM R08 exp436	1.81
Pifithrin-alpha 20μM R07 exp390	1.81
Hydroxyurea 100μM R07 exp329	1.82
BI-D1870 2μM R04 exp162	1.87
Clomiphene 4.4μM R02 exp68	1.88
2-Methoxyestradiol 0.55μM R07 exp310	1.89
Mubritinib 0.2μM R01 exp48	1.94
MK-1775 0.32μM R02 exp75	1.99
Temozolomide 200μM R04 exp189	2.07
L-74142 5μM R03 exp131	2.2
Rapamycin 10μM R00 exp30	2.24
UM0125461 0.74μM R02 exp84	2.26
Genistein 15μM R07 exp360	2.34
Oligomycin-A 2μM R00 exp25	2.44

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial ribosome assembly
positive regulation of mitochondrial translation
regulation of mitochondrial translation
regulation of mitochondrial gene expression
mitochondrial large ribosomal subunit
ribosome assembly
positive regulation of translation
positive regulation of cellular amide metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
regulation of translation
mitochondrial inner membrane
regulation of cellular amide metabolic process
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
organelle assembly
cellular protein-containing complex assembly
protein-containing complex assembly
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process