SFXN4

Entrez Summary: This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014].
UniProt Summary: Potential iron transporter. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	1.7
Trientine 500μM R08 exp534	1.72
NMS-873 0.07μM R07 exp380	1.76
CCT251545 0.2μM R06 exp271	1.77
Adefovir 20μM R07 exp332	1.79
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.81
Mdivi-1 15μM R05 exp217	1.81
Ribavirin 10 to 15μM on day4 R04 exp160	1.81
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.89
Hydroxyurea 100μM R07 exp329	2.06
Resveratrol 16μM R03 exp147	2.17
Rapamycin 0.001μM R08 exp429	2.31
Oligomycin-A 2μM R00 exp25	2.33
Ribavirin 10μM R01 exp52	2.74
Temozolomide 200μM R04 exp189	2.89
HMS-I2 10μM R06 exp288	3.69

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ion transmembrane transporter activity
amino acid transport
organic acid transport
carboxylic acid transport
mitochondrial inner membrane
organic anion transport
anion transport
intracellular membrane-bounded organelle
ion transmembrane transport
mitochondrion
transmembrane transport
ion transport
nitrogen compound transport