PREPL

Entrez Summary: The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Citral 50μM R06 exp274	-1.96
Taxol 0.004μM R03 exp103	1.7
LY2090314 0.003μM R08 exp500 no dilution day6	1.71
Quercetin 20μM R08 exp517	1.73
Arsenate 40μM R06 exp264	1.74
Adefovir 20μM R07 exp332	1.77
Pterostilbene 16μM R02 exp78	1.78
Dynasore 10μM R04 exp180	1.86
Hydroxyurea 100μM R07 exp329	1.92
QNZ 0.01μM R05 exp241	1.97
Dimethyloxaloylglycine 100μM R05 exp229	2.01
MK-1775 0.32μM R02 exp75	2.03
FTY720 3μM R08 exp483	2.07
Torin1 0.08μM R02 exp82	2.07
FK-506 30μM R07 exp359	2.11
Ibrutinib 10μM R08 exp442	2.18
Clomiphene 4.4μM R02 exp68	2.21
Oligomycin-A 2μM R00 exp25	2.27
Vinblastine 0.002μM R01 exp60	2.33
Azithromycin 100μM R08 exp452	2.38
UM0125461 0.74μM R02 exp84	2.4
Tubacin 1.6μM R07 exp416	2.49
Mubritinib 0.2μM R02 exp65	2.52
BI-6727 0.0125μM R03 exp97	2.84

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase S9
Peptidase S9 N

serine-type exopeptidase activity
Golgi to plasma membrane protein transport
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
regulation of synaptic vesicle exocytosis
peptidase activity
vesicle-mediated transport to the plasma membrane
retrograde transport, endosome to Golgi
post-Golgi vesicle-mediated transport
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
regulation of neurotransmitter transport
cytosolic transport
regulation of regulated secretory pathway
serine-type endopeptidase activity
trans-Golgi network
protein localization to plasma membrane
regulation of exocytosis
protein localization to cell periphery
endosomal transport
establishment of protein localization to membrane
regulation of neurotransmitter levels
cytoskeleton
Golgi vesicle transport
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
protein localization to membrane
regulation of vesicle-mediated transport
regulation of secretion by cell
regulation of secretion
regulation of cellular localization
Golgi apparatus
proteolysis
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization