Pterostilbene 16μM R02 exp78

Putative sirtuin activator, anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, anti-obesity, analog of resveratrol

PubChem Name: Pterostilbene
Synonyms: N/A
CAS #: 537-42-8
PubChem CID: 5281727
IUPAC: 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
INCHI Name: InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
INCHI Key: VLEUZFDZJKSGMX-ONEGZZNKSA-N
Molecular Weight: 256.3
Canonical SMILES: COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC
Isomeric SMILES: COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC
Molecular Formula: C16H16O3

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
20/7	Scores	View	View	View	View	View

Screen	Correlation	Plot
Resveratrol 16μM R03 exp147	0.123	View
UM0125461 0.74μM R02 exp84	0.094	View
Thimerosal 0.85μM R08 exp529	0.083	View
Quercetin 20μM R08 exp517	0.079	View
Trimetrexate 0.03μM R08 exp535	0.07	View
WYE-354 6μM R02 exp90	0.061	View
Talazoparib 0.006μM R06 exp299	0.059	View
UMK57 1μM R01 exp59	0.054	View
Rucaparib 6.5μM R08 exp520	0.054	View
Sulforaphane 9μM R08 exp525	0.052	View
Hydroxyurea 100μM R07 exp329	0.14	View
Aphidicolin 0.4μM R08 exp440	0.096	View
MK-1775 0.32μM R02 exp75	0.09	View
FK-506 30μM R07 exp359	0.078	View
Olaparib 4μM R08 exp512	0.075	View
Genistein 15μM R07 exp360	0.068	View
Nutlin-3A 1.6μM R06 exp294	0.067	View
Diepoxybutane 3μM R07 exp354	0.063	View
Dynasore 7μM R08 exp436	0.06	View
Cryptotanshinone 12μM R05 exp227	0.054	View
Dynasore 10μM R04 exp180	0.054	View
BVD-523 15μM R02 exp67	0.053	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.052	View
Calcium Ionophore 0.4μM R07 exp342	0.051	View

GO Term	Fold Change	Genes
tRNA aminoacylation	52.65	WARS2,LARS2,DARS2,QRSL1
amino acid activation	51.42	WARS2,LARS2,DARS2,QRSL1
mitochondrial translation	25.83	MRPS34,WARS2,LARS2,DARS2,QRSL1
mitochondrial gene expression	23.86	MRPS34,HSD17B10,WARS2,LARS2,DARS2,QRSL1
tRNA metabolic process	14.78	HSD17B10,WARS2,LARS2,DARS2,QRSL1
translation	12.28	MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1
peptide biosynthetic process	11.49	MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1
mitochondrial matrix	10.47	IBA57,MRPS34,MECR,HSD17B10,WARS2,GLRX5,LARS2,DARS2,MALSU1
peptide metabolic process	9.27	MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1
amide biosynthetic process	8.74	MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1
amide metabolic process	6.55	MRPS34,PMVK,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1

GO Term	Fold Change	Genes
sphinganine metabolic process	592.29	SPTLC2,SPTLC1
serine C-palmitoyltransferase activity	296.14	SPTLC2,SPTLC1