STYX

Gene Information

Official Symbol: STYX
Official Name: serine/threonine/tyrosine interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 6815
UniProt: Q8WUJ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011].
UniProt Summary: Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:23847209}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK626616 14μM R08 exp485	-2.7
RS-1 10μM R08 exp519	-2.42
Pterostilbene 16μM R02 exp78	-2.28
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.16
Resveratrol 16μM R03 exp147	-2.14
FK-506 30μM R07 exp359	-2.1
Dorsomorphin 5μM R07 exp357	-1.93
R-DABN 8μM R03 exp111	-1.92
Milciclib 2μM R08 exp502	-1.87
CAY10603 0.55μM R08 exp467	-1.7
Trientine 500μM R08 exp534	1.84

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14848
Expression level (log2 read counts): 5.34

Expression Distribution

negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
pseudophosphatase activity
F-box domain binding
MAPK export from nucleus
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
protein tyrosine/serine/threonine phosphatase activity
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
negative regulation of protein binding
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein catabolic process
protein export from nucleus
regulation of ubiquitin-dependent protein catabolic process
nuclear export
negative regulation of binding
regulation of proteasomal protein catabolic process
protein dephosphorylation
regulation of proteolysis involved in cellular protein catabolic process
regulation of protein binding
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
nucleocytoplasmic transport
nuclear transport
regulation of ERK1 and ERK2 cascade
dephosphorylation
negative regulation of catabolic process
negative regulation of proteolysis
regulation of binding
regulation of protein catabolic process
regulation of proteolysis
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of cellular catabolic process
regulation of catabolic process
intracellular protein transport
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process