RECQL5

Entrez Summary: The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
UniProt Summary: Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to camptothecin
replication-born double-strand break repair via sister chromatid exchange
four-way junction helicase activity
response to camptothecin
RNA polymerase II, holoenzyme
negative regulation of transcription elongation from RNA polymerase II promoter
DNA unwinding involved in DNA replication
negative regulation of DNA-templated transcription, elongation
3-5 DNA helicase activity
negative regulation of double-strand break repair via homologous recombination
regulation of transcription elongation from RNA polymerase II promoter
chromosome separation
negative regulation of double-strand break repair
RNA polymerase II complex binding
negative regulation of DNA repair
cellular response to alkaloid
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
regulation of DNA-templated transcription, elongation
DNA helicase activity
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
cellular response to alcohol
response to antineoplastic agent
double-strand break repair via homologous recombination
recombinational repair
regulation of DNA recombination
DNA duplex unwinding
response to alkaloid
DNA geometric change
DNA-dependent DNA replication
negative regulation of DNA metabolic process
chromosome
regulation of DNA repair
double-strand break repair
nucleic acid binding
DNA replication
regulation of response to DNA damage stimulus
DNA recombination
response to alcohol