SLFN11

Entrez Summary: N/A
UniProt Summary: Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon- usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage. {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.91
Etoposide 1μM R00 exp19	-1.95
Artemisinin 50μM R08 exp450	1.74
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.95
Atovaquone 15μM R08 exp451	2.11
Resveratrol 16μM R03 exp147	2.32
AICAR 240μM R03 exp116	2.33
TRAIL 5ng/ml R00 exp35	2.41
Trimetrexate 0.03μM R08 exp535	2.51
Cryptotanshinone 12μM R05 exp227	2.56
Dynasore 7μM R08 exp436	2.59
Rucaparib 6.5μM R08 exp520	2.65
Quercetin 20μM R08 exp517	2.85
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.97
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	3.02
Hydroxyurea 100μM R07 exp329	3.08
Deferoxamine 11μM R07 exp350	3.15
3-Bromopyruvate 7μM R04 exp175	3.25
AICAR 240μM R05 exp211	3.34
Nutlin-3A 1.6μM R06 exp294	3.65
Dynasore 10μM R04 exp180	3.81
Aphidicolin 0.4μM R08 exp440	3.93
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	4.3
Pterostilbene 16μM R02 exp78	4.61
MK-1775 0.32μM R02 exp75	5.16
Mitomycin-C 0.06μM R08 exp503	6.41
Diepoxybutane 3μM R07 exp354	6.47
Olaparib 4μM R08 exp512	6.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

replication fork arrest
site of DNA damage
negative regulation of DNA-dependent DNA replication
helicase activity
DNA-dependent DNA replication maintenance of fidelity
negative regulation of DNA replication
aggresome
regulation of DNA-dependent DNA replication
tRNA binding
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
regulation of DNA replication
DNA-dependent DNA replication
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
defense response to virus
negative regulation of mitotic cell cycle phase transition
DNA replication
negative regulation of cell cycle phase transition
ATPase activity
response to virus
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
negative regulation of cell cycle
regulation of mitotic cell cycle
positive regulation of cell death
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
defense response to other organism
immune effector process
regulation of cell cycle
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
negative regulation of cellular macromolecule biosynthetic process
negative regulation of macromolecule biosynthetic process