SLFN11 [The Human Chemical-Genetic Interaction Map Project]

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======= SLFN11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLFN11
  * **<color #00a2e8>Official Name</color>**: schlafen family member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91607|91607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z7L1|Q7Z7L1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLFN11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLFN11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614953|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon- usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage. {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|replication fork arrest|
|site of DNA damage|
|negative regulation of DNA-dependent DNA replication|
|helicase activity|
|DNA-dependent DNA replication maintenance of fidelity|
|negative regulation of DNA replication|
|aggresome|
|regulation of DNA-dependent DNA replication|
|tRNA binding|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|regulation of DNA replication|
|DNA-dependent DNA replication|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|defense response to virus|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|negative regulation of cell cycle phase transition|
|ATPase activity|
|response to virus|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|positive regulation of cell death|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|defense response to other organism|
|immune effector process|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.91|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.95|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.74|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.95|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.11|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.32|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.33|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.41|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.51|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.56|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.59|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.65|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.85|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.97|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|3.02|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|3.08|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.15|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.25|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.34|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.65|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|3.81|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.93|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|4.3|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|4.61|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|5.16|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|6.41|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|6.47|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|6.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nsun2|NSUN2]]|0.608|
|[[:human genes:r:rmi1|RMI1]]|0.524|
|[[:human genes:r:rmi2|RMI2]]|0.506|
|[[:human genes:z:znf330|ZNF330]]|0.469|
|[[:human genes:p:pml|PML]]|0.463|
|[[:human genes:i:irf1|IRF1]]|0.448|
|[[:human genes:b:blm|BLM]]|0.417|
|[[:human genes:t:trmt2a|TRMT2A]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15684
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLFN11 Expression in NALM6 Cells: 8.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>