Pterostilbene 16μM R02 exp78 [The Human Chemical-Genetic Interaction Map Project]

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====== Pterostilbene 16μM R02 exp78 ======
==== Mechanism of Action ====
Putative sirtuin activator, anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, anti-obesity, analog of resveratrol
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Activator




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Pterostilbene%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 537-42-8
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5281727|5281727]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
    * **<color #00a2e8>INCHI Key:</color>** VLEUZFDZJKSGMX-ONEGZZNKSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 256.3
    * **<color #00a2e8>Canonical SMILES:</color>** COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC
    * **<color #00a2e8>Isomeric SMILES:</color>** COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC
    * **<color #00a2e8>Molecular Formula:</color>** C16H16O3
{{:chemogenomics:structures:chem-0054.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** P1499
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C16H16O3 257.11722; found 257.11778
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Pterostilbene
    * **<color #00a2e8>Min:</color>** -0.1319; **<color #00a2e8>Max:</color>** 93.8385
{{:chemogenomics:dose_response:dr_21.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |14.8329    |
| IC30  |17.6499    |
| IC40  |20.3537    |
| IC50  |23.1980    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 16µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.9
    * **<color #00a2e8>Numbers of reads</color>**: 14016474


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|20/7|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Pterostilbene_16uM_Round-2_exp78.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Pterostilbene 16μM R02 exp78'>
{{:chemogenomics:cranks_plots:exp78.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:C:CCDC111|CCDC111]]|-4.30|<0.01|
|[[:human_genes:R:RECQL5|RECQL5]]|-3.89|<0.01|
|[[:human_genes:A:ADIPOR2|ADIPOR2]]|-3.78|<0.01|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-3.59|<0.01|
|[[:human_genes:G:GTPBP2|GTPBP2]]|-3.36|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.27|<0.01|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.91|<0.01|
|[[:human_genes:M:MSI2|MSI2]]|-2.82|<0.01|
|[[:human_genes:K:KPNA4|KPNA4]]|-2.77|<0.01|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.70|0.03|
|[[:human_genes:B:BCOR|BCOR]]|-2.69|0.01|
|[[:human_genes:A:ANKRD32|ANKRD32]]|-2.63|0.03|
|[[:human_genes:S:SMC1A|SMC1A]]|-2.62|0.48|
|[[:human_genes:P:PPIL1|PPIL1]]|-2.55|0.07|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.50|0.03|
|[[:human_genes:D:DDX3X|DDX3X]]|-2.50|0.03|
|[[:human_genes:C:CCDC82|CCDC82]]|-2.49|0.05|
|[[:human_genes:Z:ZBTB1|ZBTB1]]|-2.45|0.05|
|[[:human_genes:R:RANBP1|RANBP1]]|-2.41|0.04|
|[[:human_genes:P:PKMYT1|PKMYT1]]|-2.41|0.11|
|[[:human_genes:B:BIRC5|BIRC5]]|-2.41|0.27|
|[[:human_genes:F:FBXW7|FBXW7]]|-2.40|0.04|
|[[:human_genes:P:PCGF1|PCGF1]]|-2.39|0.04|
|[[:human_genes:A:ACSL4|ACSL4]]|-2.37|0.07|
|[[:human_genes:F:FBXO7|FBXO7]]|-2.36|0.05|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.35|0.05|
|[[:human_genes:S:SPTLC1|SPTLC1]]|-2.32|0.05|
|[[:human_genes:S:STYX|STYX]]|-2.28|0.11|
|[[:human_genes:G:GFPT1|GFPT1]]|-2.28|0.16|
|[[:human_genes:W:WDR26|WDR26]]|-2.28|0.16|
|[[:human_genes:M:MALSU1|MALSU1]]|2.19|0.12|
|[[:human_genes:T:TOR3A|TOR3A]]|2.20|0.12|
|[[:human_genes:P:PIK3CD|PIK3CD]]|2.20|0.15|
|[[:human_genes:E:EIF4G3|EIF4G3]]|2.24|0.14|
|[[:human_genes:D:DARS2|DARS2]]|2.25|0.20|
|[[:human_genes:Z:ZFC3H1|ZFC3H1]]|2.27|0.13|
|[[:human_genes:L:LARS2|LARS2]]|2.27|0.13|
|[[:human_genes:G:GLRX5|GLRX5]]|2.29|0.23|
|[[:human_genes:W:WARS2|WARS2]]|2.29|0.12|
|[[:human_genes:Z:ZCCHC8|ZCCHC8]]|2.30|0.12|
|[[:human_genes:R:RMI2|RMI2]]|2.30|0.08|
|[[:human_genes:H:HSD17B10|HSD17B10]]|2.31|0.12|
|[[:human_genes:C:CDK2|CDK2]]|2.32|0.08|
|[[:human_genes:G:GCN1L1|GCN1L1]]|2.35|0.08|
|[[:human_genes:C:CCNL1|CCNL1]]|2.36|0.08|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.40|0.10|
|[[:human_genes:C:CDC25A|CDC25A]]|2.52|0.08|
|[[:human_genes:P:PMVK|PMVK]]|2.52|0.08|
|[[:human_genes:S:SLC43A3|SLC43A3]]|2.55|0.04|
|[[:human_genes:H:HCCS|HCCS]]|2.57|0.14|
|[[:human_genes:M:MECR|MECR]]|2.62|0.06|
|[[:human_genes:F:FADS2|FADS2]]|2.65|0.08|
|[[:human_genes:H:HK2|HK2]]|2.67|0.18|
|[[:human_genes:M:MRPS34|MRPS34]]|2.69|0.02|
|[[:human_genes:K:KLF16|KLF16]]|2.76|0.04|
|[[:human_genes:W:WDR83|WDR83]]|2.92|0.02|
|[[:human_genes:U:USMG5|USMG5]]|2.95|0.30|
|[[:human_genes:I:IBA57|IBA57]]|3.20|<0.01|
|[[:human_genes:P:PET117|PET117]]|3.36|<0.01|
|[[:human_genes:S:SLFN11|SLFN11]]|4.61|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|0.123|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.094|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.083|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.079|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.07|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.061|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|0.059|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.054|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.054|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.052|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.14|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.096|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|0.09|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.078|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.075|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.068|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.067|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.063|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|0.06|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.054|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.054|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.053|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|0.052|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|0.051|<button type="primary" size="small" modal="24">View</button>|
</modal>


<modal id="1" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp78.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Pterostilbene 16μM R02 exp78  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp78_vs_exp84.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp529_vs_exp78.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp517_vs_exp78.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp535_vs_exp78.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Pterostilbene 16μM R02 exp78  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp78_vs_exp90.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Talazoparib 0.006μM R06 exp299">
{{:chemogenomics:comparison_plots:exp299_vs_exp78.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Pterostilbene 16μM R02 exp78  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp59_vs_exp78.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Rucaparib 6.5μM R08 exp520">
{{:chemogenomics:comparison_plots:exp520_vs_exp78.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp525_vs_exp78.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp329_vs_exp78.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp440_vs_exp78.png?nolink |}}
</modal>

<modal id="13" size="lg" title="MK-1775 0.32μM R02 exp75  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp75_vs_exp78.png?nolink |}}
</modal>

<modal id="14" size="lg" title="FK-506 30μM R07 exp359  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp359_vs_exp78.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Olaparib 4μM R08 exp512  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp512_vs_exp78.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Genistein 15μM R07 exp360  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp360_vs_exp78.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Nutlin-3A 1.6μM R06 exp294  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp294_vs_exp78.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp354_vs_exp78.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Dynasore 7μM R08 exp436  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp436_vs_exp78.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp227_vs_exp78.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Dynasore 10μM R04 exp180  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp180_vs_exp78.png?nolink |}}
</modal>

<modal id="22" size="lg" title="BVD-523 15μM R02 exp67  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp67_vs_exp78.png?nolink |}}
</modal>

<modal id="23" size="lg" title="2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp312_vs_exp78.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Calcium Ionophore 0.4μM R07 exp342  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp342_vs_exp78.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|sphinganine metabolic process|592.29|SPTLC2,SPTLC1|
|serine C-palmitoyltransferase activity|296.14|SPTLC2,SPTLC1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|tRNA aminoacylation|52.65|WARS2,LARS2,DARS2,QRSL1|
|amino acid activation|51.42|WARS2,LARS2,DARS2,QRSL1|
|mitochondrial translation|25.83|MRPS34,WARS2,LARS2,DARS2,QRSL1|
|mitochondrial gene expression|23.86|MRPS34,HSD17B10,WARS2,LARS2,DARS2,QRSL1|
|tRNA metabolic process|14.78|HSD17B10,WARS2,LARS2,DARS2,QRSL1|
|translation|12.28|MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1|
|peptide biosynthetic process|11.49|MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1|
|mitochondrial matrix|10.47|IBA57,MRPS34,MECR,HSD17B10,WARS2,GLRX5,LARS2,DARS2,MALSU1|
|peptide metabolic process|9.27|MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1|
|amide biosynthetic process|8.74|MRPS34,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1|
|amide metabolic process|6.55|MRPS34,PMVK,EIF4A1,GCN1,WARS2,LARS2,DARS2,EIF4G3,QRSL1|
</modal>