SLC30A9

Entrez Summary: N/A
UniProt Summary: Acts as a zinc transporter involved in intracellular zinc homeostasis (PubMed:28334855). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity). {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-1.87
Mubritinib 0.2μM R02 exp65	1.7
Demecolcine 0.03μM R05 exp228	1.71
S-trityl-L-cysteine 0.5μM R05 exp243	1.72
HMS-I1 1μM R01 exp46	1.74
BML-284 0.09μM R08 exp460	1.78
UMK57 1μM R01 exp59	1.81
Epigallocatechin gallate 20μM R05 exp230	1.86
Mubritinib 0.2μM R01 exp48	1.89
Rifampicin 10μM R00 exp32	1.96
Clomiphene 4.4μM R02 exp68	2
Hippuristanol 0.12μM R08 exp488	2.18
Tubacin 1.6μM R07 exp416	2.52
Oligomycin-A 2μM R00 exp25	2.86

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cation transmembrane transporter activity
nuclear receptor binding
zinc ion transport
cellular zinc ion homeostasis
zinc ion homeostasis
nuclear receptor transcription coactivator activity
cellular transition metal ion homeostasis
nucleotide-excision repair
transition metal ion transport
transition metal ion homeostasis
cytoplasmic vesicle
divalent metal ion transport
divalent inorganic cation transport
cytoskeleton
chromatin binding
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
DNA repair
cellular metal ion homeostasis
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
DNA-binding transcription factor activity
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
DNA metabolic process
cellular response to DNA damage stimulus
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
endoplasmic reticulum
chemical homeostasis
positive regulation of transcription by RNA polymerase II
transmembrane transport
ion transport
positive regulation of transcription, DNA-templated