PDSS2

Entrez Summary: The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009].
UniProt Summary: Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. {ECO:0000269|PubMed:16262699}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.4μM R03 exp99	-1.76
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.72
Hydroxyurea 100μM R07 exp329	1.72
Pterostilbene 16μM R02 exp78	1.78
Dynasore 7μM R08 exp436	1.84
KU-0063794 3.8μM R02 exp71	1.92
AICAR 240μM R03 exp116	2.07
Ribavirin 10μM R01 exp52	2.34
HMS-I1 1μM R01 exp46	2.35
Ammonium tetrathiomolybdate 10μM R08 exp448	3.54

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

trans-hexaprenyltranstransferase activity
trans-octaprenyltranstransferase activity
transferase complex
quinone biosynthetic process
ubiquinone biosynthetic process
ubiquinone metabolic process
ketone biosynthetic process
isoprenoid biosynthetic process
quinone metabolic process
protein heterotetramerization
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
protein heterooligomerization
coenzyme biosynthetic process
isoprenoid metabolic process
protein tetramerization
cofactor biosynthetic process
coenzyme metabolic process
mitochondrial matrix
cofactor metabolic process
protein heterodimerization activity
regulation of body fluid levels
protein complex oligomerization
lipid biosynthetic process
small molecule biosynthetic process
cellular lipid metabolic process
lipid metabolic process
protein-containing complex assembly
small molecule metabolic process
protein-containing complex subunit organization