TOMM7

Gene Information

Official Symbol: TOMM7
Official Name: translocase of outer mitochondrial membrane 7
Aliases and Previous Symbols: N/A
Entrez ID: 54543
UniProt: Q9P0U1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. {ECO:0000269|PubMed:18331822, ECO:0000269|PubMed:24270810}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol S 100μM R08 exp458	-2.1
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.72
Lead acetate 2000μM R08 exp498 no dilution day6	1.76
CoCl2 18μM R07 exp346	1.84
LY2090314 0.003μM R08 exp499	1.84
SB743921 0.001μM R05 exp244	1.85
CAY10603 0.55μM R08 exp467	1.93
Rotenone 2μM R00 exp33	1.96
UM0125461 0.74μM R02 exp84	2.16
LY2090314 0.003μM R08 exp500 no dilution day6	2.31
Oligomycin-A 2μM R00 exp25	2.54

Gene	Correlation
LARS2	0.494
GFM1	0.473
NDUFS5	0.466
RMND1	0.45
MRPS21	0.448
NARS2	0.447
MRP63	0.445
FTSJ2	0.443
FASTKD2	0.441
VARS2	0.434
NDUFA11	0.424
MRPS6	0.423
PNPT1	0.423
MARS2	0.42
MRPL21	0.419
ERAL1	0.416
RTN4IP1	0.412
NDUFAF7	0.41
GTPBP6	0.41
NDUFA3	0.41
DAP3	0.406
TFB1M	0.405
RPUSD4	0.402
TRIT1	0.401
MRPL20	0.4
MRPS23	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4923
Expression level (log2 read counts): 5.77

Expression Distribution

positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of mitophagy
mitochondrial outer membrane translocase complex
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of mitophagy
response to mitochondrial depolarisation
protein import into mitochondrial matrix
positive regulation of autophagy of mitochondrion
protein transmembrane transporter activity
positive regulation of protein targeting to mitochondrion
protein transmembrane import into intracellular organelle
regulation of autophagy of mitochondrion
regulation of protein targeting to mitochondrion
intracellular protein transmembrane transport
protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
protein transmembrane transport
positive regulation of macroautophagy
establishment of protein localization to mitochondrion
regulation of establishment of protein localization to mitochondrion
protein localization to mitochondrion
regulation of protein targeting
mitochondrial transmembrane transport
positive regulation of mitochondrion organization
positive regulation of autophagy
protein import
positive regulation of intracellular protein transport
macroautophagy
mitochondrial outer membrane
regulation of macroautophagy
regulation of mitochondrion organization
positive regulation of intracellular transport
mitochondrial transport
regulation of intracellular protein transport
autophagy
process utilizing autophagic mechanism
regulation of protein stability
positive regulation of cellular protein localization
regulation of autophagy