MRPL44

Gene Information

Official Symbol: MRPL44
Official Name: mitochondrial ribosomal protein L44
Aliases and Previous Symbols: N/A
Entrez ID: 65080
UniProt: Q9H9J2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. {ECO:0000269|PubMed:23315540}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
MRPL21	0.592
MRP63	0.592
MRPL23	0.585
MRPS25	0.566
MRPS6	0.562
MRPS9	0.558
MTG2	0.548
YARS2	0.543
HSD17B10	0.543
SELRC1	0.541
NDUFAF7	0.537
MRPS21	0.537
SUPV3L1	0.534
MRPS34	0.533
NDUFA3	0.532
NDUFB11	0.531
PARS2	0.529
RPUSD4	0.528
MRPS5	0.526
DAP3	0.525
COX16	0.525
TIMMDC1	0.521
TARS2	0.521
FTSJ2	0.521
GFM1	0.519
MTPAP	0.518
NARS2	0.517
WBSCR16	0.516
GTPBP10	0.514
NDUFC2	0.514
SCO2	0.513
MRPL45	0.512
MTRF1L	0.512
QRSL1	0.511
MRPS16	0.507
VARS2	0.505
MRPL53	0.504
DARS2	0.504
MRPL17	0.503
MRPS26	0.501
SARS2	0.497
GFM2	0.497
EARS2	0.496
MRPS18A	0.496
MRPS12	0.496
LARS2	0.494
COA3	0.493
NDUFS2	0.492
MRPL47	0.491
FARS2	0.49
COQ2	0.49
MRPS24	0.489
BCS1L	0.488
PET117	0.486
FASTKD5	0.485
KIAA0391	0.485
MRPL18	0.485
COX6C	0.484
NDUFA1	0.482
NDUFA11	0.478
MRPS14	0.478
MRPS23	0.476
TRUB2	0.476
PNPT1	0.474
AIFM1	0.473
NDUFAF3	0.471
MRPS33	0.47
CHCHD1	0.47
COQ4	0.469
MRPL20	0.468
NDUFB9	0.468
C10orf2	0.466
COA6	0.463
NDUFA2	0.463
TUFM	0.459
MRPL33	0.459
ACAD9	0.458
MRPS10	0.458
MTERFD2	0.457
COQ7	0.456
COQ5	0.456
C12orf65	0.456
CLPP	0.455
MRPS2	0.455
PET112	0.452
CARS2	0.452
HMGXB3	0.451
MTG1	0.451
UQCR10	0.45
NDUFAF6	0.45
TIMM8B	0.449
METTL17	0.448
AARS2	0.448
MRPL55	0.448
COX15	0.447
MALSU1	0.446
MTERFD1	0.446
MRPL15	0.446
MRPS22	0.445
NDUFS7	0.445
COQ3	0.444
MRPL3	0.443
TEFM	0.441
RBFA	0.441
RNASEH1	0.44
PTCD3	0.439
MRPL34	0.438
NUBPL	0.438
COX7B	0.437
TFB1M	0.437
ELAC2	0.435
MRPL42	0.434
COX11	0.434
HARS2	0.433
FASTKD2	0.433
POLG2	0.432
MRPL43	0.432
IBA57	0.432
RARS2	0.431
MRPS11	0.43
NDUFAF4	0.43
MRPL9	0.43
PITRM1	0.43
UQCRC2	0.429
NDUFA6	0.426
NDUFB5	0.425
MARS2	0.425
MRPL22	0.424
SSBP1	0.423
NDUFC1	0.423
ATP5C1	0.422
MRPL13	0.421
POLRMT	0.421
MRPS27	0.419
NDUFB6	0.419
ERAL1	0.415
RTN4IP1	0.414
DDX28	0.414
MRPL12	0.413
MRPL35	0.412
FOXRED1	0.412
TOMM20	0.41
NDUFS5	0.41
GRSF1	0.41
RPUSD3	0.41
MRPS28	0.409
TIMM17A	0.409
PDSS1	0.408
MRPL41	0.408
DHX30	0.405
WARS2	0.403
MRPL4	0.403
C17orf89	0.402

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1126
Expression level (log2 read counts): 5.05

Expression Distribution

Screen	Score
Thimerosal 0.85μM R08 exp529	1.86
Mitomycin-C 0.06μM R08 exp503	2.1
GSK-J4 1.5μM R08 exp441	2.22

ribonuclease III activity
primary miRNA processing
production of siRNA involved in RNA interference
pre-miRNA processing
RNA interference
production of miRNAs involved in gene silencing by miRNA
dsRNA processing
production of small RNA involved in gene silencing by RNA
gene silencing by miRNA
posttranscriptional gene silencing by RNA
mitochondrial large ribosomal subunit
posttranscriptional gene silencing
double-stranded RNA binding
RNA phosphodiester bond hydrolysis, endonucleolytic
gene silencing by RNA
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
gene silencing
RNA phosphodiester bond hydrolysis
regulation of gene expression, epigenetic
protein-containing complex disassembly
nucleic acid phosphodiester bond hydrolysis
translation
ncRNA processing
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
ncRNA metabolic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
RNA processing
mitochondrion
RNA binding