MRPL44 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL44
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L44
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65080|65080]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9J2|Q9H9J2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. {ECO:0000269|PubMed:23315540}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonuclease III activity|
|primary miRNA processing|
|production of siRNA involved in RNA interference|
|pre-miRNA processing|
|RNA interference|
|production of miRNAs involved in gene silencing by miRNA|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|mitochondrial large ribosomal subunit|
|posttranscriptional gene silencing|
|double-stranded RNA binding|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|gene silencing by RNA|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|gene silencing|
|RNA phosphodiester bond hydrolysis|
|regulation of gene expression, epigenetic|
|protein-containing complex disassembly|
|nucleic acid phosphodiester bond hydrolysis|
|translation|
|ncRNA processing|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.1|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.592|
|[[:human genes:m:mrp63|MRP63]]|0.592|
|[[:human genes:m:mrpl23|MRPL23]]|0.585|
|[[:human genes:m:mrps25|MRPS25]]|0.566|
|[[:human genes:m:mrps6|MRPS6]]|0.562|
|[[:human genes:m:mrps9|MRPS9]]|0.558|
|[[:human genes:m:mtg2|MTG2]]|0.548|
|[[:human genes:y:yars2|YARS2]]|0.543|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.543|
|[[:human genes:s:selrc1|SELRC1]]|0.541|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.537|
|[[:human genes:m:mrps21|MRPS21]]|0.537|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.534|
|[[:human genes:m:mrps34|MRPS34]]|0.533|
|[[:human genes:n:ndufa3|NDUFA3]]|0.532|
|[[:human genes:n:ndufb11|NDUFB11]]|0.531|
|[[:human genes:p:pars2|PARS2]]|0.529|
|[[:human genes:r:rpusd4|RPUSD4]]|0.528|
|[[:human genes:m:mrps5|MRPS5]]|0.526|
|[[:human genes:d:dap3|DAP3]]|0.525|
|[[:human genes:c:cox16|COX16]]|0.525|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.521|
|[[:human genes:t:tars2|TARS2]]|0.521|
|[[:human genes:f:ftsj2|FTSJ2]]|0.521|
|[[:human genes:g:gfm1|GFM1]]|0.519|
|[[:human genes:m:mtpap|MTPAP]]|0.518|
|[[:human genes:n:nars2|NARS2]]|0.517|
|[[:human genes:w:wbscr16|WBSCR16]]|0.516|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.514|
|[[:human genes:n:ndufc2|NDUFC2]]|0.514|
|[[:human genes:s:sco2|SCO2]]|0.513|
|[[:human genes:m:mrpl45|MRPL45]]|0.512|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.512|
|[[:human genes:q:qrsl1|QRSL1]]|0.511|
|[[:human genes:m:mrps16|MRPS16]]|0.507|
|[[:human genes:v:vars2|VARS2]]|0.505|
|[[:human genes:m:mrpl53|MRPL53]]|0.504|
|[[:human genes:d:dars2|DARS2]]|0.504|
|[[:human genes:m:mrpl17|MRPL17]]|0.503|
|[[:human genes:m:mrps26|MRPS26]]|0.501|
|[[:human genes:s:sars2|SARS2]]|0.497|
|[[:human genes:g:gfm2|GFM2]]|0.497|
|[[:human genes:e:ears2|EARS2]]|0.496|
|[[:human genes:m:mrps18a|MRPS18A]]|0.496|
|[[:human genes:m:mrps12|MRPS12]]|0.496|
|[[:human genes:l:lars2|LARS2]]|0.494|
|[[:human genes:c:coa3|COA3]]|0.493|
|[[:human genes:n:ndufs2|NDUFS2]]|0.492|
|[[:human genes:m:mrpl47|MRPL47]]|0.491|
|[[:human genes:f:fars2|FARS2]]|0.49|
|[[:human genes:c:coq2|COQ2]]|0.49|
|[[:human genes:m:mrps24|MRPS24]]|0.489|
|[[:human genes:b:bcs1l|BCS1L]]|0.488|
|[[:human genes:p:pet117|PET117]]|0.486|
|[[:human genes:f:fastkd5|FASTKD5]]|0.485|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.485|
|[[:human genes:m:mrpl18|MRPL18]]|0.485|
|[[:human genes:c:cox6c|COX6C]]|0.484|
|[[:human genes:n:ndufa1|NDUFA1]]|0.482|
|[[:human genes:n:ndufa11|NDUFA11]]|0.478|
|[[:human genes:m:mrps14|MRPS14]]|0.478|
|[[:human genes:m:mrps23|MRPS23]]|0.476|
|[[:human genes:t:trub2|TRUB2]]|0.476|
|[[:human genes:p:pnpt1|PNPT1]]|0.474|
|[[:human genes:a:aifm1|AIFM1]]|0.473|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.471|
|[[:human genes:m:mrps33|MRPS33]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.47|
|[[:human genes:c:coq4|COQ4]]|0.469|
|[[:human genes:m:mrpl20|MRPL20]]|0.468|
|[[:human genes:n:ndufb9|NDUFB9]]|0.468|
|[[:human genes:c:c10orf2|C10orf2]]|0.466|
|[[:human genes:c:coa6|COA6]]|0.463|
|[[:human genes:n:ndufa2|NDUFA2]]|0.463|
|[[:human genes:t:tufm|TUFM]]|0.459|
|[[:human genes:m:mrpl33|MRPL33]]|0.459|
|[[:human genes:a:acad9|ACAD9]]|0.458|
|[[:human genes:m:mrps10|MRPS10]]|0.458|
|[[:human genes:m:mterfd2|MTERFD2]]|0.457|
|[[:human genes:c:coq7|COQ7]]|0.456|
|[[:human genes:c:coq5|COQ5]]|0.456|
|[[:human genes:c:c12orf65|C12orf65]]|0.456|
|[[:human genes:c:clpp|CLPP]]|0.455|
|[[:human genes:m:mrps2|MRPS2]]|0.455|
|[[:human genes:p:pet112|PET112]]|0.452|
|[[:human genes:c:cars2|CARS2]]|0.452|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.451|
|[[:human genes:m:mtg1|MTG1]]|0.451|
|[[:human genes:u:uqcr10|UQCR10]]|0.45|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.45|
|[[:human genes:t:timm8b|TIMM8B]]|0.449|
|[[:human genes:m:mettl17|METTL17]]|0.448|
|[[:human genes:a:aars2|AARS2]]|0.448|
|[[:human genes:m:mrpl55|MRPL55]]|0.448|
|[[:human genes:c:cox15|COX15]]|0.447|
|[[:human genes:m:malsu1|MALSU1]]|0.446|
|[[:human genes:m:mterfd1|MTERFD1]]|0.446|
|[[:human genes:m:mrpl15|MRPL15]]|0.446|
|[[:human genes:m:mrps22|MRPS22]]|0.445|
|[[:human genes:n:ndufs7|NDUFS7]]|0.445|
|[[:human genes:c:coq3|COQ3]]|0.444|
|[[:human genes:m:mrpl3|MRPL3]]|0.443|
|[[:human genes:t:tefm|TEFM]]|0.441|
|[[:human genes:r:rbfa|RBFA]]|0.441|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.44|
|[[:human genes:p:ptcd3|PTCD3]]|0.439|
|[[:human genes:m:mrpl34|MRPL34]]|0.438|
|[[:human genes:n:nubpl|NUBPL]]|0.438|
|[[:human genes:c:cox7b|COX7B]]|0.437|
|[[:human genes:t:tfb1m|TFB1M]]|0.437|
|[[:human genes:e:elac2|ELAC2]]|0.435|
|[[:human genes:m:mrpl42|MRPL42]]|0.434|
|[[:human genes:c:cox11|COX11]]|0.434|
|[[:human genes:h:hars2|HARS2]]|0.433|
|[[:human genes:f:fastkd2|FASTKD2]]|0.433|
|[[:human genes:p:polg2|POLG2]]|0.432|
|[[:human genes:m:mrpl43|MRPL43]]|0.432|
|[[:human genes:i:iba57|IBA57]]|0.432|
|[[:human genes:r:rars2|RARS2]]|0.431|
|[[:human genes:m:mrps11|MRPS11]]|0.43|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.43|
|[[:human genes:m:mrpl9|MRPL9]]|0.43|
|[[:human genes:p:pitrm1|PITRM1]]|0.43|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.429|
|[[:human genes:n:ndufa6|NDUFA6]]|0.426|
|[[:human genes:n:ndufb5|NDUFB5]]|0.425|
|[[:human genes:m:mars2|MARS2]]|0.425|
|[[:human genes:m:mrpl22|MRPL22]]|0.424|
|[[:human genes:s:ssbp1|SSBP1]]|0.423|
|[[:human genes:n:ndufc1|NDUFC1]]|0.423|
|[[:human genes:a:atp5c1|ATP5C1]]|0.422|
|[[:human genes:m:mrpl13|MRPL13]]|0.421|
|[[:human genes:p:polrmt|POLRMT]]|0.421|
|[[:human genes:m:mrps27|MRPS27]]|0.419|
|[[:human genes:n:ndufb6|NDUFB6]]|0.419|
|[[:human genes:e:eral1|ERAL1]]|0.415|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.414|
|[[:human genes:d:ddx28|DDX28]]|0.414|
|[[:human genes:m:mrpl12|MRPL12]]|0.413|
|[[:human genes:m:mrpl35|MRPL35]]|0.412|
|[[:human genes:f:foxred1|FOXRED1]]|0.412|
|[[:human genes:t:tomm20|TOMM20]]|0.41|
|[[:human genes:n:ndufs5|NDUFS5]]|0.41|
|[[:human genes:g:grsf1|GRSF1]]|0.41|
|[[:human genes:r:rpusd3|RPUSD3]]|0.41|
|[[:human genes:m:mrps28|MRPS28]]|0.409|
|[[:human genes:t:timm17a|TIMM17A]]|0.409|
|[[:human genes:p:pdss1|PDSS1]]|0.408|
|[[:human genes:m:mrpl41|MRPL41]]|0.408|
|[[:human genes:d:dhx30|DHX30]]|0.405|
|[[:human genes:w:wars2|WARS2]]|0.403|
|[[:human genes:m:mrpl4|MRPL4]]|0.403|
|[[:human genes:c:c17orf89|C17orf89]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1126
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL44 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>