RARS2

Gene Information

Official Symbol: RARS2
Official Name: arginyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 57038
UniProt: Q5T160
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ZLN024 50μM R08 exp538	-2.21
JQ1 0.01μM R03 exp130	-2.05
HMS-I2 5μM R06 exp287	-1.9
WNT3A 44ng/ml R08 exp537	-1.74
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.7
Amiloride 100μM R08 exp447	1.72
Nutlin-3A 1.6μM R06 exp294	1.74
Vinblastine 0.002μM R01 exp60	1.77
Hydroxyurea 100μM R07 exp329	1.79
Bisphenol A 100μM R06 exp269	1.84
CR131-b 0.005μM R08 exp474	1.89
Vemurafenib 6.6μM R08 exp434	1.89
Phenformin 20μM R03 exp143	1.91
Vinblastine 0.2μM R03 exp108	1.91
Arsenate 40μM R06 exp264	1.93
iCRT14 30μM R08 exp492	1.94
Hippuristanol 0.12μM R08 exp488	1.95
Atovaquone 15μM R08 exp451	2
GSK-J4 1.5μM R08 exp441	2.02
Aphidicolin 0.4μM R08 exp440	2.04
ONC212 0.15μM R08 exp513	2.31
Mubritinib 0.2μM R01 exp48	2.34
UM0125461 0.74μM R02 exp84	2.45
LLY-283 2.6μM R06 exp290	2.56
Oligomycin-A 2μM R00 exp25	2.97

Gene	Correlation
NARS2	0.742
HSD17B10	0.722
QRSL1	0.685
YARS2	0.674
MRPS6	0.669
MRPS21	0.669
GFM1	0.658
DAP3	0.653
MRPS14	0.652
SELRC1	0.65
PARS2	0.649
MRPS16	0.648
MRPL21	0.646
DARS2	0.641
HARS2	0.64
MARS2	0.635
MRPL23	0.629
MRPS26	0.628
TARS2	0.625
EARS2	0.618
MRPS34	0.618
LARS2	0.615
RPUSD4	0.614
AARS2	0.608
FASTKD5	0.607
COX16	0.606
VARS2	0.603
PET112	0.602
SCO2	0.599
MRP63	0.599
COA3	0.593
MRPS5	0.592
KIAA0391	0.59
GTPBP10	0.589
WBSCR16	0.586
C10orf2	0.586
MRPS25	0.579
RBFA	0.578
MRPS9	0.564
TEFM	0.564
GATC	0.563
COX7B	0.561
MRPL53	0.559
MRPL47	0.558
RPUSD3	0.557
MRPS22	0.553
BCS1L	0.552
PNPT1	0.551
MRPL20	0.549
COX11	0.549
TFB1M	0.549
MTG2	0.545
TRUB2	0.543
COX15	0.543
GFM2	0.542
MRPS18A	0.542
MRPL45	0.541
C12orf65	0.541
POLG2	0.54
PET117	0.539
SUPV3L1	0.538
MTG1	0.536
MRPL3	0.535
POLG	0.534
FTSJ2	0.534
METTL17	0.532
MRPS12	0.531
MRPL43	0.531
TUFM	0.527
NDUFAF7	0.525
RNASEH1	0.523
MRPL18	0.522
NDUFB11	0.519
MRPS10	0.519
FARS2	0.517
WARS2	0.517
CARS2	0.516
COA6	0.516
MTRF1L	0.515
PDSS1	0.515
MRPL42	0.515
MRPS35	0.514
MRPL12	0.514
NDUFA3	0.512
COX20	0.509
DNLZ	0.506
ATP5SL	0.505
TOMM20	0.503
MRPS2	0.502
COX17	0.501
MRPL15	0.496
RTN4IP1	0.493
SLC25A26	0.49
MRPS24	0.489
MTERFD1	0.488
ATP5B	0.487
MRPL33	0.486
NDUFC2	0.486
POLRMT	0.485
PGM3	0.485
MRPL51	0.485
MRPL17	0.484
MRPL4	0.484
MRPL55	0.483
TFAM	0.483
MTIF2	0.482
MRPS23	0.482
MRPL11	0.479
SARS2	0.479
DDX28	0.475
NDUFA1	0.473
ATP5C1	0.473
AIFM1	0.472
MTPAP	0.47
HMGXB3	0.47
ATP5A1	0.47
MRPS27	0.47
LSM10	0.468
ATP5D	0.467
GTPBP6	0.465
MRPS11	0.463
ELAC2	0.462
NDUFS2	0.461
PTCD3	0.461
NSUN4	0.461
MALSU1	0.46
NDUFA2	0.459
MRPL28	0.457
COX6B1	0.456
ERAL1	0.456
RNMTL1	0.454
CLPP	0.453
COX19	0.453
MRPS7	0.453
DHRSX	0.448
MRPS33	0.447
MIPEP	0.446
NDUFB9	0.445
CHCHD1	0.445
GTPBP8	0.445
ATP5H	0.445
MRPL13	0.445
C1QBP	0.443
TMEM242	0.442
TIMMDC1	0.435
GRSF1	0.434
PPA2	0.434
NDUFAF3	0.433
NUBPL	0.433
TRIAP1	0.431
MRPL44	0.431
MCAT	0.431
FASTKD1	0.43
ACAD9	0.428
TOMM22	0.428
MTERFD2	0.427
COX6C	0.427
NDUFAF4	0.427
SLC25A3	0.426
MRPL41	0.426
PTPMT1	0.426
TRMT10C	0.425
FH	0.424
NDUFA10	0.422
SSBP1	0.421
MRPS18B	0.421
MRPL38	0.419
COQ7	0.417
UQCRQ	0.417
COQ2	0.417
SLC25A52	0.416
NDUFB5	0.416
COX5A	0.416
UQCRC2	0.415
AURKAIP1	0.415
MRPL37	0.414
UQCRC1	0.411
IBA57	0.411
MRPL22	0.409
C17orf89	0.408
NDUFAF5	0.406
NDUFV1	0.405
LRPPRC	0.404
MRPL49	0.404
HCCS	0.404
MRPL39	0.402
PMVK	0.402
NDUFB3	0.402
NDUFB6	0.402
MRPL35	0.401
MRPL32	0.401
UQCC2	0.4

Global Fraction of Cell Lines Where Essential: 216/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	3/28
bone	8/26
breast	10/33
central nervous system	7/56
cervix	1/4
colorectal	6/17
esophagus	8/13
fibroblast	1/1
gastric	7/16
kidney	4/21
liver	6/20
lung	25/75
lymphocyte	6/16
ovary	1/26
pancreas	6/24
peripheral nervous system	2/16
plasma cell	8/15
prostate	0/1
skin	4/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	9/22
urinary tract	13/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 761
Expression level (log2 read counts): 4.96

Expression Distribution

DALR 1
tRNA-synt 1d

arginine-tRNA ligase activity
arginyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression