AURKAIP1

Entrez Summary: N/A
UniProt Summary: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitotic nuclear division
ribosome
negative regulation of nuclear division
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
regulation of mitotic nuclear division
regulation of nuclear division
protein-containing complex disassembly
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
positive regulation of proteolysis
negative regulation of organelle organization
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
mRNA processing
amide biosynthetic process
peptide metabolic process
negative regulation of cell cycle
regulation of mitotic cell cycle
intracellular membrane-bounded organelle
mRNA metabolic process
negative regulation of cellular component organization
regulation of proteolysis
regulation of cell cycle process
cellular amide metabolic process
RNA processing
regulation of cell cycle
mitochondrion
regulation of organelle organization
organonitrogen compound biosynthetic process
positive regulation of cellular protein metabolic process
cellular nitrogen compound biosynthetic process
RNA metabolic process