TRUB2

Gene Information

Official Symbol: TRUB2
Official Name: TruB pseudouridine synthase family member 2
Aliases and Previous Symbols: N/A
Entrez ID: 26995
UniProt: O95900
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Minor enzyme contributing to the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability. {ECO:0000269|PubMed:27974379}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lapatinib 5μM R01 exp47	-1.96
Pyridostatin 4μM R05 exp240	1.7
Atovaquone 15μM R08 exp451	1.71
LLY-283 2.6μM R06 exp290	1.72
UM131593 0.2μM R03 exp106	1.72
Dimethyloxaloylglycine 100μM R05 exp229	1.79
ONC212 0.15μM R08 exp513	1.8
TIC10 10μM R08 exp532	1.82
GSK591 2.6μM R03 exp128	1.92
CoCl2 18μM R07 exp346	1.95
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.95
Thimerosal 0.85μM R08 exp529	1.97
Oligomycin-A 2μM R00 exp25	2.01
Aphidicolin 0.4μM R08 exp440	2.03
Tanespimycin 14μM R08 exp527	2.05
UM0125461 0.74μM R02 exp84	2.09
Hydroxyurea 100μM R07 exp329	2.12
Mubritinib 0.2μM R01 exp48	2.27
GSK-J4 1.5μM R08 exp441	2.56
AICAR 240μM R05 exp211	2.61

Gene	Correlation
MRPL21	0.637
MRP63	0.613
MRPS34	0.612
YARS2	0.612
HSD17B10	0.608
MRPS12	0.598
MRPS18A	0.593
KIAA0391	0.592
MRPS16	0.59
MRPS6	0.588
MRPL23	0.583
MRPS21	0.58
MTPAP	0.568
QRSL1	0.563
SUPV3L1	0.563
VARS2	0.56
MRPL55	0.554
MRPS35	0.553
RPUSD4	0.553
MRPS25	0.553
MRPS14	0.551
DARS2	0.55
MRPL47	0.547
MRPS5	0.546
FASTKD5	0.544
RARS2	0.543
GTPBP10	0.54
PNPT1	0.54
NDUFA3	0.538
HARS2	0.535
COX16	0.533
SELRC1	0.533
MRPL3	0.533
FARS2	0.532
MRPS26	0.53
NARS2	0.528
TUFM	0.524
MRPS9	0.523
PTCD3	0.522
SARS2	0.521
DAP3	0.519
C10orf2	0.519
SCO2	0.516
NDUFB11	0.516
NDUFV1	0.515
PET112	0.515
TARS2	0.514
GFM1	0.512
FTSJ2	0.512
MARS2	0.51
PARS2	0.509
NDUFA1	0.509
DDX28	0.506
LARS2	0.506
MRPL33	0.503
RNASEH1	0.501
MRPL52	0.499
MRPL18	0.498
COX7B	0.498
RBFA	0.497
TFAM	0.496
COX6B1	0.494
MTG2	0.493
UQCR10	0.492
COA3	0.491
RNMTL1	0.49
MRPS2	0.49
MRPL42	0.489
GFM2	0.488
MRPL45	0.486
MRPS22	0.485
CLPP	0.485
EARS2	0.482
MRPL12	0.481
RPUSD3	0.481
MRPS10	0.48
MRPL20	0.48
MRPS24	0.479
C12orf65	0.479
MRPL44	0.476
TEFM	0.474
MRPS23	0.471
MRPL39	0.471
NDUFC2	0.47
CHCHD1	0.468
ACAD9	0.468
MRPS7	0.466
METTL17	0.465
MRPL53	0.464
LRPPRC	0.463
WBSCR16	0.462
GATC	0.462
SLC25A26	0.461
ATP5D	0.46
CARS2	0.46
PDSS1	0.458
MTRF1L	0.457
C17orf89	0.457
AARS2	0.456
TOMM20	0.454
MRPL41	0.453
BCS1L	0.452
NDUFB9	0.452
MRPL4	0.449
COX15	0.449
MRPL46	0.449
MRPL13	0.447
PET117	0.446
MRPL17	0.446
TRMT10C	0.446
GTPBP6	0.443
ECSIT	0.442
MTERFD2	0.442
WARS2	0.442
MRPL34	0.442
MIPEP	0.442
MRPL43	0.441
NDUFAF1	0.441
MTG1	0.441
MTERFD1	0.439
NDUFB6	0.437
MRPS27	0.436
NDUFAF7	0.436
COA6	0.435
MRPL51	0.432
COQ3	0.431
MRPL36	0.431
POLRMT	0.431
MALSU1	0.43
NDUFAF5	0.429
TIMMDC1	0.429
TFB2M	0.428
COA5	0.427
TOMM40	0.425
UQCRC1	0.425
AIFM1	0.424
NDUFS2	0.422
MRPL49	0.422
NDUFAF3	0.421
NDUFS8	0.42
TIMM8B	0.42
MTIF2	0.419
MRPL37	0.419
MRPS17	0.417
MRPL15	0.415
MRPL22	0.414
GTPBP8	0.412
NDUFA2	0.411
FASTKD2	0.41
COQ2	0.409
NDUFC1	0.408
OPA1	0.406
NDUFA6	0.405
HMGXB3	0.404
UQCRC2	0.403
NDUFB5	0.403
NDUFA11	0.403
COX6C	0.401
GLRX5	0.401
NDUFAF4	0.4
ATP5A1	0.4
MRPL2	0.4

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 454
Expression level (log2 read counts): 6.34

Expression Distribution

pseudouridine synthase activity
positive regulation of mitochondrial translation
pseudouridine synthesis
regulation of mitochondrial translation
regulation of mitochondrial gene expression
positive regulation of translation
positive regulation of cellular amide metabolic process
RNA modification
regulation of translation
mitochondrial matrix
regulation of cellular amide metabolic process
mRNA processing
posttranscriptional regulation of gene expression
mRNA metabolic process
RNA processing
RNA binding
positive regulation of cellular protein metabolic process
RNA metabolic process
positive regulation of protein metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process