COA5

Entrez Summary: This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011].
UniProt Summary: Involved in an early step of the mitochondrial complex IV assembly process. {ECO:0000269|PubMed:21457908}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex IV assembly
respiratory chain complex IV assembly
cytochrome complex assembly
mitochondrial respiratory chain complex assembly
mitochondrion organization
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization