COA3

Gene Information

Official Symbol: COA3
Official Name: cytochrome c oxidase assembly factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 28958
UniProt: Q9Y2R0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012].
UniProt Summary: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. {ECO:0000269|PubMed:23260140}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-2.17
CHIR-124 0.04μM R06 exp272	-1.74
Hypoxia 5%O2 R04 exp191	-1.71
Arsenate 40μM R06 exp264	1.7
BI-D1870 3.15μM R02 exp66	1.72
Dorsomorphin 5μM R07 exp357	1.82
Phenformin 20μM R05 exp212	1.84
Hippuristanol 0.12μM R08 exp488	1.85
Mubritinib 0.2μM R01 exp48	1.86
GSK-J4 1.5μM R08 exp441	1.88
Pterostilbene 16μM R02 exp78	1.89
Mubritinib 0.2μM R02 exp65	2.06
Ribavirin 10μM R01 exp52	2.08
Hydroxyurea 100μM R07 exp329	2.09
UM0129480 7μM R02 exp85	2.67
UM0125461 0.74μM R02 exp84	3.08

Gene	Correlation
SELRC1	0.724
PET117	0.724
NARS2	0.695
QRSL1	0.68
EARS2	0.68
SCO2	0.679
COX11	0.671
HSD17B10	0.661
COA6	0.646
FASTKD5	0.645
MRPS16	0.643
DARS2	0.641
YARS2	0.639
PET112	0.639
MRPS21	0.635
MRPS6	0.632
DAP3	0.628
VARS2	0.623
TARS2	0.616
AARS2	0.615
MRPL23	0.61
FTSJ2	0.605
MARS2	0.602
MALSU1	0.595
RPUSD4	0.594
COX16	0.594
MRPS34	0.593
RARS2	0.593
PARS2	0.592
FARS2	0.59
MRPL21	0.59
MRPS14	0.587
MRPS27	0.585
GFM1	0.583
MRPS5	0.581
LARS2	0.58
MRPS26	0.58
MRPL47	0.579
MRPS25	0.578
RBFA	0.572
BCS1L	0.569
COX15	0.567
METTL17	0.567
HARS2	0.559
POLG	0.559
MRPL49	0.559
MRPS2	0.557
MRPS12	0.556
COX7B	0.554
MRPL45	0.552
MRPL3	0.551
MRPS18A	0.549
MTG2	0.547
SARS2	0.545
MRPL53	0.544
MRPL18	0.544
NDUFB11	0.544
CARS2	0.544
DDX28	0.544
MRPS35	0.54
COA5	0.539
WARS2	0.537
TFB1M	0.534
COX17	0.534
MRPS22	0.528
GFM2	0.528
MRPL11	0.524
POLG2	0.524
MRPS24	0.523
PTCD3	0.522
C12orf65	0.521
MRPL43	0.52
MTERFD1	0.516
MRPL17	0.515
MRP63	0.515
WBSCR16	0.513
MRPL15	0.51
COX6B1	0.509
AIFM1	0.505
GTPBP10	0.504
C10orf2	0.503
MTG1	0.5
MTPAP	0.499
POLRMT	0.498
MRPL12	0.497
LRPPRC	0.497
RPUSD3	0.496
NDUFA2	0.493
TOMM20	0.493
MRPL44	0.493
NDUFAF7	0.492
TRUB2	0.491
PGM3	0.491
MIPEP	0.489
RNASEH1	0.488
MRPS10	0.487
MRPL4	0.487
NDUFA3	0.487
MRPL35	0.482
HIGD2A	0.481
NDUFAF3	0.48
MCAT	0.48
NSUN4	0.477
COQ2	0.477
MRPL22	0.474
CHCHD1	0.472
MTERFD2	0.472
SCO1	0.471
MTRF1L	0.47
MRPL20	0.468
MRPL1	0.465
ERAL1	0.464
MRPL33	0.462
ACAD9	0.462
MRPL2	0.462
GATC	0.459
ATP5C1	0.457
SUPV3L1	0.455
MRPS9	0.452
COX20	0.452
CLPP	0.452
RTN4IP1	0.451
FASTKD2	0.451
MRPL55	0.45
NDUFS2	0.45
SLC31A1	0.45
FASTKD1	0.449
MRPS7	0.447
IBA57	0.447
MRPL37	0.445
MRPL42	0.445
UQCRC2	0.444
MRPL39	0.442
GTPBP8	0.442
MRPL34	0.441
MRPL52	0.438
NDUFC2	0.437
SSBP1	0.437
NDUFV1	0.437
COX19	0.437
NDUFA1	0.435
TUFM	0.435
KIAA0391	0.434
TEFM	0.434
RNMTL1	0.433
MTO1	0.431
MRPL51	0.431
MRPS18B	0.431
PTCD1	0.429
HMGXB3	0.429
TMEM242	0.427
XPNPEP3	0.425
NUBPL	0.425
NDUFB6	0.423
MRPL32	0.423
MRPL28	0.423
MTIF2	0.421
COX6C	0.421
GRSF1	0.418
PDSS1	0.417
MRPL9	0.416
GTPBP6	0.416
NDUFAF5	0.416
MRPS28	0.413
MRPL10	0.413
PNPT1	0.412
MRPS23	0.41
PET100	0.409
SLC25A26	0.408
ECSIT	0.407
TMEM261	0.406
COX4I1	0.403
TIMMDC1	0.402
COQ4	0.4

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 185
Expression level (log2 read counts): 2.43

Expression Distribution

mitochondrial respiratory chain complex IV
positive regulation of mitochondrial translation
mitochondrial respiratory chain complex IV assembly
respiratory chain complex IV assembly
regulation of mitochondrial translation
regulation of mitochondrial gene expression
cytochrome complex assembly
integral component of mitochondrial inner membrane
mitochondrial respiratory chain complex assembly
positive regulation of translation
positive regulation of cellular amide metabolic process
regulation of translation
regulation of cellular amide metabolic process
mitochondrion organization
posttranscriptional regulation of gene expression
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process