FASTKD1

Entrez Summary: N/A
UniProt Summary: Regulates the stability of mitochondrial MT-ND3 mRNA (PubMed:28335001). {ECO:0000269|PubMed:28335001}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-839 10μM R05 exp224	-3.35
BAY-598 4μM R05 exp220	-2.1
CR131-b 0.005μM R08 exp474	1.83
UMK57 1μM R01 exp59	1.92
BVD-523 15μM R02 exp67	1.96
MK2206 4μM R08 exp504	1.98
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.06
Mubritinib 0.2μM R02 exp65	2.53
ONC212 0.15μM R08 exp513	2.61
Ammonium tetrathiomolybdate 10μM R08 exp448	2.9

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of mitochondrial mRNA stability
mitochondrial RNA metabolic process
cellular respiration
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
energy derivation by oxidation of organic compounds
protein kinase activity
regulation of mRNA metabolic process
generation of precursor metabolites and energy
posttranscriptional regulation of gene expression
regulation of cellular catabolic process
oxidation-reduction process
protein phosphorylation
regulation of catabolic process
mitochondrion
phosphorylation
RNA binding
RNA metabolic process