KIAA0391

Gene Information

Official Symbol: PRORP
Official Name: protein only RNase P catalytic subunit
Aliases and Previous Symbols: N/A
Entrez ID: 9692
UniProt: O15091
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCCP 1μM R00 exp11	-3.15
3-Bromopyruvate 7μM R04 exp175	-2.36
YM155 0.0002μM R01 exp61	-2.25
CCT251545 20μM R07 exp326	-1.8
Lapatinib 5μM R01 exp47	-1.75
TGF-beta1 44ng/ml R08 exp528	-1.75
Cyclosporin-A 3μM R07 exp348	-1.72
LLY-283 2.6μM R06 exp290	1.72
Salinomycin 3.5μM R08 exp521	1.73
Deferoxamine 11μM R07 exp350	1.79
Ammonium tetrathiomolybdate 10μM R08 exp448	1.81
CFI-400945 25μM R08 exp469	1.84
Nicotinate 1000μM R03 exp140	1.88
Trimetrexate 0.03μM R08 exp535	1.9
Vitamin-D3 40μM R08 exp536	2.05
Amiloride 100μM R08 exp447	2.07
Hydroxyurea 100μM R07 exp329	2.09
ONC212 0.15μM R08 exp513	2.5
Thimerosal 0.85μM R08 exp529	2.66
TIC10 10μM R08 exp532	2.78
GSK-J4 1.5μM R08 exp441	2.79

Gene	Correlation
MRPL21	0.685
MRPS34	0.672
MRPS14	0.669
MRPS18A	0.668
HSD17B10	0.661
YARS2	0.66
RPUSD4	0.652
MRPS6	0.65
SELRC1	0.647
SARS2	0.639
DAP3	0.639
SUPV3L1	0.631
PARS2	0.626
MRPS5	0.626
MRPL23	0.621
TARS2	0.619
MRPS16	0.614
VARS2	0.61
BCS1L	0.61
DARS2	0.608
GFM1	0.608
MRPL47	0.607
TEFM	0.606
HARS2	0.604
NARS2	0.601
COX16	0.597
QRSL1	0.597
DHRSX	0.592
TRUB2	0.592
MRPS12	0.591
RARS2	0.59
EARS2	0.589
MTPAP	0.588
SCO2	0.588
MRPL53	0.587
MRPS21	0.585
LARS2	0.58
SLC25A26	0.579
PNPT1	0.577
MRPS26	0.574
RBFA	0.574
UQCR10	0.572
MRPS9	0.57
MRPS2	0.563
MARS2	0.562
TUFM	0.562
GATC	0.561
WBSCR16	0.56
GFM2	0.557
MTG2	0.554
RNASEH1	0.551
MRPL55	0.545
FASTKD5	0.544
MRPS24	0.543
MRP63	0.541
C10orf2	0.541
UQCRC2	0.539
AARS2	0.535
TRMT10A	0.531
COX17	0.523
GTPBP10	0.52
TRIAP1	0.518
COX7B	0.518
FARS2	0.516
ELAC2	0.514
MRPS10	0.514
MRPS33	0.512
TRMT61A	0.512
MRPL12	0.51
MRPS23	0.508
C17orf89	0.508
PDSS1	0.508
MRPS25	0.508
COX6C	0.508
COQ3	0.506
NDUFB11	0.505
NDUFAF7	0.503
MRPL20	0.503
NDUFA3	0.503
COA6	0.503
MRPL33	0.502
MRPL18	0.501
MRPL36	0.499
MRPL3	0.49
PPA2	0.49
ATP5D	0.49
MRPL15	0.488
ATP5B	0.488
DOHH	0.488
THG1L	0.487
TOMM20	0.487
FTSJ2	0.486
MRPL44	0.485
DNLZ	0.482
C12orf65	0.482
PGM3	0.481
LSM10	0.48
SSB	0.479
MRPS17	0.478
CRLS1	0.478
ALG6	0.477
UAP1	0.477
TMEM242	0.476
PMM2	0.475
MRPL42	0.474
PPCS	0.472
KDSR	0.471
TAZ	0.471
ATP5A1	0.47
TFAM	0.47
CHCHD4	0.47
COX15	0.47
PITRM1	0.469
MRPS35	0.469
TMEM126B	0.467
MRPS11	0.467
RPIA	0.467
OPA1	0.467
COQ2	0.464
PET112	0.464
MRPL34	0.464
DHX30	0.463
NDUFAF4	0.463
TPK1	0.462
UQCRQ	0.461
MRPL4	0.461
MTIF3	0.461
TOMM22	0.46
FH	0.457
ROMO1	0.457
POLG2	0.456
MTG1	0.455
SEC62	0.454
DPAGT1	0.454
RPUSD3	0.453
ATIC	0.453
MRPL39	0.452
MRPS7	0.451
MTERFD2	0.451
WARS2	0.451
ATP5O	0.451
MRPL41	0.45
MRPL11	0.447
COA5	0.447
AIFM1	0.446
MINOS1	0.445
NDUFC2	0.443
LRPPRC	0.443
MIPEP	0.442
CARS2	0.442
COX5A	0.442
MRPL52	0.441
COQ7	0.439
COX11	0.437
MRPL13	0.437
ATXN10	0.436
AASDHPPT	0.436
GFPT1	0.436
METTL17	0.436
NDUFB5	0.435
COA3	0.434
HCCS	0.433
UHRF1	0.433
NDUFAF3	0.43
NDUFA2	0.43
TAMM41	0.43
TOMM40	0.429
ZRSR2	0.428
TIMM8B	0.428
LSM11	0.427
COX6B1	0.425
ALG8	0.424
NDUFV1	0.423
NDUFA1	0.422
ATP5SL	0.422
MTRF1L	0.422
MRPL46	0.421
ALG13	0.421
ATP5H	0.42
TTC4	0.417
DOLK	0.416
MRPS22	0.416
ATP5C1	0.415
MRPL27	0.415
POLRMT	0.415
NDUFB9	0.413
RPE	0.413
VEZT	0.413
TMEM41B	0.411
PTRHD1	0.411
PTPMT1	0.41
CYCS	0.409
MBTPS2	0.408
URM1	0.408
POLG	0.407
ALDH18A1	0.406
PDCD5	0.406
MRPL17	0.404
CBFB	0.403
MRPL22	0.402
NDUFB6	0.402

Global Fraction of Cell Lines Where Essential: 91/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	2/26
breast	8/33
central nervous system	4/56
cervix	3/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	2/21
liver	4/20
lung	14/75
lymphocyte	2/16
ovary	1/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 795
Expression level (log2 read counts): 5.99

Expression Distribution

mitochondrial tRNA 5-end processing
mitochondrial ribonuclease P complex
mitochondrial RNA 5-end processing
mitochondrial tRNA methylation
mitochondrial tRNA modification
mitochondrial RNA modification
ribonuclease P activity
tRNA 5-leader removal
mitochondrial tRNA processing
tRNA 5-end processing
tRNA threonylcarbamoyladenosine metabolic process
mitochondrial RNA processing
ncRNA 5-end processing
RNA 5-end processing
tRNA methylation
mitochondrial RNA metabolic process
mitochondrial nucleoid
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA methylation
tRNA modification
tRNA processing
mitochondrial gene expression
RNA phosphodiester bond hydrolysis
RNA modification
tRNA metabolic process
macromolecule methylation
nucleic acid phosphodiester bond hydrolysis
methylation
mitochondrial matrix
ncRNA processing
ncRNA metabolic process
RNA processing
mitochondrion
RNA metabolic process
gene expression