TAMM41

Official Symbol: TAMM41
Official Name: TAM41 mitochondrial translocator assembly and maintenance homolog
Aliases and Previous Symbols: N/A
Entrez ID: 132001
UniProt: Q96BW9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 610/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	27/28
blood	23/28
bone	22/26
breast	22/33
central nervous system	49/56
cervix	4/4
colorectal	12/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	19/21
liver	18/20
lung	61/75
lymphocyte	13/16
ovary	24/26
pancreas	22/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	1/1
skin	21/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	3/5

Expression Distribution

phosphatidate cytidylyltransferase activity
cardiolipin biosynthetic process
phosphatidylglycerol biosynthetic process
cardiolipin metabolic process
CDP-diacylglycerol biosynthetic process
extrinsic component of mitochondrial inner membrane
CDP-diacylglycerol metabolic process
phosphatidylglycerol metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine-containing compound metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
lipid metabolic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process