TAMM41 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TAMM41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAMM41
  * **<color #00a2e8>Official Name</color>**: TAM41 mitochondrial translocator assembly and maintenance homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=132001|132001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BW9|Q96BW9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAMM41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAMM41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mmp37|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidate cytidylyltransferase activity|
|cardiolipin biosynthetic process|
|phosphatidylglycerol biosynthetic process|
|cardiolipin metabolic process|
|CDP-diacylglycerol biosynthetic process|
|extrinsic component of mitochondrial inner membrane|
|CDP-diacylglycerol metabolic process|
|phosphatidylglycerol metabolic process|
|pyrimidine nucleotide biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|pyrimidine-containing compound metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|nucleotide biosynthetic process|
|phospholipid biosynthetic process|
|nucleoside phosphate biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.7|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.74|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.79|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.83|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.87|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.88|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.2|
|[[:results:exp539|42°C R08 exp539]]|2.35|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.36|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.42|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.51|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:triap1|TRIAP1]]|0.661|
|[[:human genes:p:pmm2|PMM2]]|0.653|
|[[:human genes:c:crls1|CRLS1]]|0.62|
|[[:human genes:h:hars|HARS]]|0.594|
|[[:human genes:t:taz|TAZ]]|0.592|
|[[:human genes:r:romo1|ROMO1]]|0.59|
|[[:human genes:a:alg1|ALG1]]|0.582|
|[[:human genes:u:uap1|UAP1]]|0.577|
|[[:human genes:t:thg1l|THG1L]]|0.57|
|[[:human genes:r:rpe|RPE]]|0.566|
|[[:human genes:d:dnlz|DNLZ]]|0.548|
|[[:human genes:o:opa1|OPA1]]|0.545|
|[[:human genes:d:dpagt1|DPAGT1]]|0.541|
|[[:human genes:h:hccs|HCCS]]|0.536|
|[[:human genes:a:alg2|ALG2]]|0.534|
|[[:human genes:t:timm13|TIMM13]]|0.534|
|[[:human genes:a:alg13|ALG13]]|0.533|
|[[:human genes:g:gmppb|GMPPB]]|0.531|
|[[:human genes:g:gfpt1|GFPT1]]|0.528|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.526|
|[[:human genes:s:slc25a26|SLC25A26]]|0.525|
|[[:human genes:g:gemin6|GEMIN6]]|0.512|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.511|
|[[:human genes:d:dohh|DOHH]]|0.507|
|[[:human genes:m:mrps14|MRPS14]]|0.507|
|[[:human genes:p:pgs1|PGS1]]|0.503|
|[[:human genes:t:ten1|TEN1]]|0.5|
|[[:human genes:s:srp14|SRP14]]|0.499|
|[[:human genes:e:exoc4|EXOC4]]|0.498|
|[[:human genes:r:rpia|RPIA]]|0.493|
|[[:human genes:c:chchd4|CHCHD4]]|0.493|
|[[:human genes:a:atxn10|ATXN10]]|0.493|
|[[:human genes:p:pam16|PAM16]]|0.492|
|[[:human genes:h:hspd1|HSPD1]]|0.49|
|[[:human genes:m:mrpl23|MRPL23]]|0.49|
|[[:human genes:p:pggt1b|PGGT1B]]|0.489|
|[[:human genes:r:rnmt|RNMT]]|0.485|
|[[:human genes:p:pgm3|PGM3]]|0.485|
|[[:human genes:r:rtcb|RTCB]]|0.485|
|[[:human genes:m:mrpl21|MRPL21]]|0.485|
|[[:human genes:d:dhrsx|DHRSX]]|0.484|
|[[:human genes:t:trnt1|TRNT1]]|0.483|
|[[:human genes:p:ppa2|PPA2]]|0.483|
|[[:human genes:a:atp5a1|ATP5A1]]|0.483|
|[[:human genes:r:rpp21|RPP21]]|0.482|
|[[:human genes:a:apaf1|APAF1]]|0.479|
|[[:human genes:t:tkt|TKT]]|0.478|
|[[:human genes:e:eif3f|EIF3F]]|0.477|
|[[:human genes:v:vezt|VEZT]]|0.477|
|[[:human genes:e:elac2|ELAC2]]|0.475|
|[[:human genes:y:yars2|YARS2]]|0.474|
|[[:human genes:a:aars|AARS]]|0.472|
|[[:human genes:g:gemin8|GEMIN8]]|0.471|
|[[:human genes:d:dpf2|DPF2]]|0.471|
|[[:human genes:g:gnb1l|GNB1L]]|0.471|
|[[:human genes:b:bak1|BAK1]]|0.469|
|[[:human genes:c:cep57|CEP57]]|0.468|
|[[:human genes:r:rptor|RPTOR]]|0.468|
|[[:human genes:t:tpi1|TPI1]]|0.468|
|[[:human genes:p:ppcs|PPCS]]|0.466|
|[[:human genes:a:alg5|ALG5]]|0.464|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.464|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.461|
|[[:human genes:s:sars2|SARS2]]|0.459|
|[[:human genes:t:tsen54|TSEN54]]|0.459|
|[[:human genes:a:atp5b|ATP5B]]|0.458|
|[[:human genes:m:mrps18a|MRPS18A]]|0.458|
|[[:human genes:p:pisd|PISD]]|0.457|
|[[:human genes:p:pelo|PELO]]|0.456|
|[[:human genes:z:zrsr2|ZRSR2]]|0.454|
|[[:human genes:n:nae1|NAE1]]|0.454|
|[[:human genes:m:mrps2|MRPS2]]|0.453|
|[[:human genes:m:mrps6|MRPS6]]|0.451|
|[[:human genes:d:ddx55|DDX55]]|0.451|
|[[:human genes:a:atp5o|ATP5O]]|0.45|
|[[:human genes:d:dhps|DHPS]]|0.449|
|[[:human genes:u:uhrf1|UHRF1]]|0.448|
|[[:human genes:d:dap3|DAP3]]|0.447|
|[[:human genes:a:atp5j|ATP5J]]|0.446|
|[[:human genes:t:tufm|TUFM]]|0.446|
|[[:human genes:c:casp9|CASP9]]|0.444|
|[[:human genes:m:msto1|MSTO1]]|0.444|
|[[:human genes:p:plaa|PLAA]]|0.444|
|[[:human genes:h:hars2|HARS2]]|0.444|
|[[:human genes:l:lsm11|LSM11]]|0.443|
|[[:human genes:k:kdsr|KDSR]]|0.443|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:a:adsl|ADSL]]|0.442|
|[[:human genes:c:cycs|CYCS]]|0.439|
|[[:human genes:r:rpusd4|RPUSD4]]|0.438|
|[[:human genes:u:ube2g2|UBE2G2]]|0.437|
|[[:human genes:m:mrps34|MRPS34]]|0.437|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.436|
|[[:human genes:f:fastkd5|FASTKD5]]|0.434|
|[[:human genes:a:atp5c1|ATP5C1]]|0.432|
|[[:human genes:c:csnk2b|CSNK2B]]|0.43|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.43|
|[[:human genes:a:atic|ATIC]]|0.429|
|[[:human genes:d:dars2|DARS2]]|0.426|
|[[:human genes:d:dusp12|DUSP12]]|0.426|
|[[:human genes:a:alg6|ALG6]]|0.426|
|[[:human genes:g:gemin7|GEMIN7]]|0.425|
|[[:human genes:t:tbca|TBCA]]|0.425|
|[[:human genes:r:rbfa|RBFA]]|0.424|
|[[:human genes:m:med16|MED16]]|0.423|
|[[:human genes:s:sco2|SCO2]]|0.423|
|[[:human genes:b:brwd1|BRWD1]]|0.42|
|[[:human genes:c:cct7|CCT7]]|0.418|
|[[:human genes:c:c15orf41|C15orf41]]|0.417|
|[[:human genes:p:ppcdc|PPCDC]]|0.416|
|[[:human genes:b:bap1|BAP1]]|0.416|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.415|
|[[:human genes:p:pdss1|PDSS1]]|0.414|
|[[:human genes:t:tmem242|TMEM242]]|0.414|
|[[:human genes:f:fnta|FNTA]]|0.413|
|[[:human genes:v:vars2|VARS2]]|0.413|
|[[:human genes:m:mbtps2|MBTPS2]]|0.413|
|[[:human genes:m:mrps16|MRPS16]]|0.412|
|[[:human genes:t:ttc4|TTC4]]|0.412|
|[[:human genes:b:bcs1l|BCS1L]]|0.411|
|[[:human genes:t:tars2|TARS2]]|0.411|
|[[:human genes:e:eno1|ENO1]]|0.411|
|[[:human genes:c:cdipt|CDIPT]]|0.409|
|[[:human genes:a:alg8|ALG8]]|0.409|
|[[:human genes:n:nsmce1|NSMCE1]]|0.405|
|[[:human genes:o:oraov1|ORAOV1]]|0.403|
|[[:human genes:r:rpn1|RPN1]]|0.403|
|[[:human genes:t:tsen34|TSEN34]]|0.402|
|[[:human genes:t:tti1|TTI1]]|0.402|
|[[:human genes:c:cept1|CEPT1]]|0.401|
|[[:human genes:m:mrps9|MRPS9]]|0.4|
|[[:human genes:t:tgs1|TGS1]]|0.4|
|[[:human genes:g:g6pd|G6PD]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 610/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|23/28|
|bone|22/26|
|breast|22/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|19/21|
|liver|18/20|
|lung|61/75|
|lymphocyte|13/16|
|ovary|24/26|
|pancreas|22/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1116
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAMM41 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>