CYCS

Gene Information

Official Symbol: CYCS
Official Name: cytochrome c, somatic
Aliases and Previous Symbols: N/A
Entrez ID: 54205
UniProt: P99999
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010].
UniProt Summary: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	1.71
Senexin-A 25μM R07 exp400	1.74
ONC212 0.15μM R08 exp513	1.84
MLN-4924 2μM R00 exp22	1.87
Dinaciclib 0.007μM R07 exp355	1.88
Vinblastine 0.015μM R05 exp208	1.89
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.9
UM0125461 0.74μM R02 exp84	1.9
LLY-283 2.6μM R06 exp290	1.91
Staurosporine 0.02μM R08 exp524	1.95
Bortezomib 0.05μM R00 exp7	1.97
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.01
RO-3307 4.7μM R02 exp80	2.01
CB-5083 0.4μM R08 exp468	2.04
SNS-032 25μM R07 exp401	2.04
42°C R08 exp539	2.1
UM0129480 7μM R02 exp85	2.13
Hippuristanol 0.12μM R08 exp488	2.14
Mitomycin-C 0.06μM R08 exp503	2.14
Latrunculin-B 10μM R07 exp374	2.16
Diepoxybutane 3μM R07 exp354	2.17
Nocodazole 0.2μM R00 exp24	2.21
Dorsomorphin 5μM R07 exp357	2.28
SB743921 0.001μM R05 exp244	2.3
Thimerosal 0.85μM R08 exp529	2.3
Hydroxyurea 100μM R07 exp329	2.33
R-DABN 8μM R03 exp111	2.33
Tozasertib 0.1μM R07 exp414	2.34
Deferoxamine 11μM R07 exp350	2.36
CI-1040 9.5μM R08 exp472	2.41
PU-H71 1μM R08 exp515	2.55
Vinblastine 0.2μM R03 exp108	2.57
AICAR 240μM R03 exp116	2.58
Benzoate 20000μM R08 exp456	2.58
Pyridostatin 4μM R05 exp240	2.59
SNS-032 15μM R08 exp443	2.61
JQ1 0.8μM R08 exp435	2.65
Tanespimycin 14μM R08 exp527	2.76
GSK626616 14μM R08 exp485	2.77
AICAR 240μM R05 exp211	2.82
Aphidicolin 0.4μM R08 exp440	2.83
Trimetrexate 0.03μM R08 exp535	2.9
Rotenone 2μM R00 exp33	3.03
GSK-J4 1.5μM R08 exp441	3.26
Olaparib 4μM R08 exp512	3.36
Doxorubicin 0.02μM R08 exp478	3.41
THZ1 0.06μM R08 exp531	3.41
Etoposide 1μM R00 exp19	3.64
Etoposide 0.3μM R05 exp199	3.88
CR131-b 0.005μM R08 exp474	4.07
MS023 7μM R03 exp135	4.41
Rotenone 20μM R00 exp34	4.57
Actinomycin-D 0.001μM R00 exp3	4.8
5-Fluorouracil 20μM R00 exp2	4.9
Pimelic-diphenylamide-106 5μM R00 exp28	5.02

Gene	Correlation
HCCS	0.762
BAK1	0.745
APAF1	0.742
CASP9	0.728
MARCH5	0.707
VDAC2	0.667
UBQLN1	0.628
PLAA	0.609
FAF2	0.595
DIABLO	0.591
DOHH	0.588
SERF2	0.586
TRIAP1	0.581
MFN1	0.573
ATP5J	0.567
HSPD1	0.561
CRLS1	0.557
ENY2	0.554
HARS	0.553
GFPT1	0.539
PPA2	0.534
TUFM	0.527
UAP1	0.516
GABPA	0.515
BAP1	0.513
SLC25A26	0.511
STAU1	0.511
OPA1	0.51
RPTOR	0.503
GMPPB	0.501
TIMM13	0.5
METAP2	0.499
DAP3	0.498
NUPL2	0.495
UQCRC2	0.493
PNPT1	0.491
ROMO1	0.491
MRPS14	0.487
ATAD1	0.485
CSNK2B	0.482
THG1L	0.481
NXT1	0.48
PMM2	0.476
BRWD1	0.475
MTOR	0.475
TAZ	0.473
ATP5A1	0.471
ATP5I	0.468
ATP5B	0.468
COX16	0.467
HSD17B10	0.462
MRPS16	0.461
MRPL21	0.457
SUPV3L1	0.456
ATP5D	0.456
COA5	0.456
FASTKD5	0.454
MRPL47	0.454
MEAF6	0.453
GFER	0.453
ATP5F1	0.45
EIF3F	0.449
SUV420H1	0.449
LAMTOR5	0.444
ALG5	0.443
SEC61G	0.443
MRPS2	0.443
UBE2K	0.442
UBE2G2	0.442
THOC6	0.44
TAMM41	0.439
BCS1L	0.437
ATP5O	0.437
RNMT	0.436
DHX30	0.436
MRPS18A	0.435
NSD1	0.429
RPUSD4	0.428
MRP63	0.428
MTPAP	0.428
DARS2	0.428
FECH	0.427
SEC16A	0.427
MRPS6	0.427
PAM16	0.424
SRP14	0.423
LSM10	0.42
SSB	0.42
COX17	0.42
LAMTOR4	0.419
KCTD5	0.419
MRPS9	0.418
SARS2	0.417
KDSR	0.415
SELRC1	0.414
CEPT1	0.414
MRPS5	0.414
UQCR10	0.414
WDR24	0.413
PRKRIR	0.412
COX7B	0.412
DHPS	0.411
DPAGT1	0.411
PISD	0.411
RPE	0.411
ATXN10	0.41
MIOS	0.409
KIAA0391	0.409
GFM1	0.408
PGM3	0.407
ATP5C1	0.407
DDHD2	0.404
ATP5L	0.404
MRPL23	0.402

Global Fraction of Cell Lines Where Essential: 383/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	17/28
blood	17/28
bone	10/26
breast	23/33
central nervous system	17/56
cervix	4/4
colorectal	11/17
esophagus	10/13
fibroblast	0/1
gastric	9/16
kidney	10/21
liver	11/20
lung	43/75
lymphocyte	8/16
ovary	10/26
pancreas	17/24
peripheral nervous system	8/16
plasma cell	10/15
prostate	0/1
skin	15/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	7/22
urinary tract	13/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 555
Expression level (log2 read counts): 7.76

Expression Distribution

electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
respirasome
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
mitochondrial electron transport, ubiquinol to cytochrome c
protein phosphatase type 2A complex
aerobic electron transport chain
mitochondrial electron transport, cytochrome c to oxygen
protein serine/threonine phosphatase activity
mitochondrial intermembrane space
aerobic respiration
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
heme binding
positive regulation of cysteine-type endopeptidase activity
cellular respiration
positive regulation of endopeptidase activity
electron transport chain
positive regulation of peptidase activity
ATP metabolic process
protein dephosphorylation
regulation of cysteine-type endopeptidase activity involved in apoptotic process
energy derivation by oxidation of organic compounds
cellular response to oxidative stress
regulation of cysteine-type endopeptidase activity
dephosphorylation
positive regulation of proteolysis
response to oxidative stress
mitochondrial inner membrane
regulation of endopeptidase activity
generation of precursor metabolites and energy
mitochondrion organization
regulation of peptidase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis