ATP5I

Gene Information

Official Symbol: ATP5ME
Official Name: ATP synthase membrane subunit e
Aliases and Previous Symbols: N/A
Entrez ID: 521
UniProt: P56385
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
WNT3A 44ng/ml R08 exp537	-1.71
Phenformin 20μM R05 exp212	1.73
AICAR 240μM R05 exp211	1.75
UM131593 0.2μM R03 exp106	1.8
Doxorubicin 0.02μM R08 exp478	1.82
MS023 7μM R03 exp135	1.89
Actinomycin-D 0.001μM R00 exp3	1.92
NMS-873 0.07μM R07 exp380	1.96
Olaparib 4μM R08 exp512	2.13
Mubritinib 0.2μM R01 exp48	2.15
Hippuristanol 0.12μM R08 exp488	2.32
Pimelic-diphenylamide-106 5μM R00 exp28	2.37
Cannabidiol 20μM R08 exp466	2.53

Gene	Correlation
ATP5B	0.586
ATP5D	0.572
ATP5J	0.559
ATP5C1	0.543
ATP5O	0.539
ATP5A1	0.537
ATP5F1	0.516
ATP5L	0.516
UBE2G2	0.478
HCCS	0.473
ENY2	0.471
FAF2	0.471
CYCS	0.468
CASP9	0.467
PLAA	0.465
GFPT1	0.456
OPA1	0.449
TRIAP1	0.446
DOHH	0.445
APAF1	0.437
KDSR	0.43
HSPD1	0.427
SERF2	0.406
GMPPB	0.404
ATP5H	0.404
CBFB	0.404
THG1L	0.404
UAP1	0.402

Global Fraction of Cell Lines Where Essential: 185/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	4/28
bone	2/26
breast	7/33
central nervous system	9/56
cervix	2/4
colorectal	5/17
esophagus	7/13
fibroblast	0/1
gastric	6/16
kidney	6/21
liver	12/20
lung	23/75
lymphocyte	2/16
ovary	5/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	6/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	7/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2179
Expression level (log2 read counts): 4.93

Expression Distribution

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
proton transmembrane transporter activity
mitochondrial proton-transporting ATP synthase complex
mitochondrial ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
ATP synthesis coupled proton transport
cristae formation
ATP biosynthetic process
inner mitochondrial membrane organization
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate metabolic process
transmembrane transporter activity
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
mitochondrial transmembrane transport
nucleoside triphosphate metabolic process
oxidative phosphorylation
mitochondrial membrane organization
proton transmembrane transport
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
ATP metabolic process
mitochondrial transport
ATPase activity
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
protein-containing complex binding
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
mitochondrial inner membrane
monovalent inorganic cation transport