MRPL55
Gene Information
- Official Symbol: MRPL55
- Official Name: mitochondrial ribosomal protein L55
- Aliases and Previous Symbols: N/A
- Entrez ID: 128308
- UniProt: Q7Z7F7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Mitoc L55 |
GO Terms
| mitochondrial large ribosomal subunit |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 2-Deoxy-D-glucose 800μM R05 exp214 | -2.36 |
| A-395N 10μM R05 exp219 | -1.93 |
| 42°C R08 exp539 | 1.86 |
| GSK591 2.6μM R03 exp128 | 2.04 |
| GSK-J4 1.5μM R08 exp441 | 2.3 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MRPS34 | 0.613 |
| HSD17B10 | 0.609 |
| MRPS5 | 0.609 |
| MTPAP | 0.591 |
| MRPL21 | 0.579 |
| RPUSD4 | 0.573 |
| MRPL23 | 0.567 |
| MRPS21 | 0.56 |
| MRPS18A | 0.555 |
| TRUB2 | 0.554 |
| VARS2 | 0.55 |
| C12orf65 | 0.546 |
| KIAA0391 | 0.545 |
| SARS2 | 0.544 |
| MRPL53 | 0.544 |
| MRPS2 | 0.543 |
| YARS2 | 0.533 |
| SUPV3L1 | 0.532 |
| C17orf89 | 0.532 |
| MRPS12 | 0.531 |
| MRPS9 | 0.529 |
| TARS2 | 0.527 |
| GFM1 | 0.527 |
| FASTKD5 | 0.526 |
| GTPBP10 | 0.523 |
| SELRC1 | 0.523 |
| MRP63 | 0.523 |
| GFM2 | 0.518 |
| COX6C | 0.517 |
| TEFM | 0.516 |
| C10orf2 | 0.515 |
| COQ2 | 0.515 |
| MRPS6 | 0.515 |
| MRPL12 | 0.514 |
| QRSL1 | 0.514 |
| MRPS24 | 0.512 |
| MTG2 | 0.511 |
| NDUFB11 | 0.508 |
| MRPS14 | 0.505 |
| MRPS26 | 0.501 |
| MRPL47 | 0.499 |
| COX15 | 0.498 |
| FARS2 | 0.498 |
| MRPS16 | 0.493 |
| DARS2 | 0.492 |
| MRPS25 | 0.49 |
| SCO2 | 0.49 |
| NDUFA3 | 0.488 |
| TUFM | 0.487 |
| EARS2 | 0.487 |
| MRPS10 | 0.486 |
| MRPS35 | 0.484 |
| RARS2 | 0.483 |
| PDSS1 | 0.477 |
| MRPL15 | 0.472 |
| NDUFA2 | 0.472 |
| MTG1 | 0.471 |
| COX16 | 0.47 |
| BCS1L | 0.47 |
| FTSJ2 | 0.468 |
| PARS2 | 0.465 |
| WBSCR16 | 0.461 |
| DAP3 | 0.46 |
| MRPL18 | 0.458 |
| MRPS23 | 0.452 |
| NARS2 | 0.451 |
| COA3 | 0.45 |
| RBFA | 0.45 |
| MRPL44 | 0.448 |
| PET112 | 0.448 |
| LRPPRC | 0.444 |
| MRPL46 | 0.443 |
| MRPL34 | 0.443 |
| MARS2 | 0.443 |
| TMEM242 | 0.443 |
| MRPS22 | 0.441 |
| RNASEH1 | 0.44 |
| DHX30 | 0.44 |
| ECSIT | 0.439 |
| MRPS11 | 0.438 |
| UQCR10 | 0.437 |
| COA6 | 0.437 |
| MRPL20 | 0.436 |
| LARS2 | 0.435 |
| MRPL43 | 0.434 |
| MTERFD2 | 0.434 |
| COX6B1 | 0.434 |
| UQCRC2 | 0.433 |
| NDUFC2 | 0.432 |
| MRPL4 | 0.432 |
| CHCHD1 | 0.431 |
| NDUFAF3 | 0.431 |
| TFAM | 0.429 |
| HARS2 | 0.429 |
| PNPT1 | 0.428 |
| PET117 | 0.425 |
| COX17 | 0.424 |
| COQ3 | 0.424 |
| MTRF1L | 0.423 |
| MRPL17 | 0.423 |
| NDUFAF7 | 0.422 |
| TIMM8B | 0.42 |
| MRPL42 | 0.42 |
| NDUFB2 | 0.419 |
| ATP5D | 0.418 |
| AARS2 | 0.418 |
| MRPL3 | 0.414 |
| GATC | 0.411 |
| MRPL49 | 0.41 |
| MRPL45 | 0.41 |
| UQCRFS1 | 0.409 |
| MCAT | 0.408 |
| MRPL13 | 0.408 |
| MRPL2 | 0.407 |
| NDUFS7 | 0.407 |
| RPUSD3 | 0.405 |
| COA5 | 0.405 |
| TOMM40 | 0.404 |
| MRPL11 | 0.404 |
| MRPL35 | 0.402 |
| CHCHD4 | 0.402 |
| NDUFB3 | 0.402 |
| METTL17 | 0.402 |
| MRPL52 | 0.401 |
| MRPL36 | 0.401 |
| HMGXB3 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 60/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 3/28 |
| bone | 2/26 |
| breast | 3/33 |
| central nervous system | 3/56 |
| cervix | 1/4 |
| colorectal | 2/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 3/21 |
| liver | 2/20 |
| lung | 10/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 2/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 2/9 |
| thyroid | 0/2 |
| upper aerodigestive | 5/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1661
- Expression level (log2 read counts): 4.4
Expression Distribution
MRPL55 Expression in NALM6 Cells: 4.4
