TOMM20

Entrez Summary: N/A
UniProt Summary: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 288/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	8/28
blood	17/28
bone	14/26
breast	8/33
central nervous system	26/56
cervix	2/4
colorectal	7/17
esophagus	3/13
fibroblast	1/1
gastric	9/16
kidney	6/21
liver	4/20
lung	24/75
lymphocyte	2/16
ovary	5/26
pancreas	8/24
peripheral nervous system	2/16
plasma cell	9/15
prostate	1/1
skin	8/24
soft tissue	3/9
thyroid	2/2
upper aerodigestive	11/22
urinary tract	15/29
uterus	1/5

Expression Distribution

tRNA import into mitochondrion
mitochondrial outer membrane translocase complex assembly
response to 3,3,5-triiodo-L-thyronine
mitochondrion targeting sequence binding
RNA import into mitochondrion
outer mitochondrial membrane organization
P-P-bond-hydrolysis-driven protein transmembrane transporter activity
mitochondrial outer membrane translocase complex
mitochondria-associated endoplasmic reticulum membrane
protein transmembrane transporter activity
protein import into mitochondrial matrix
integral component of mitochondrial outer membrane
response to muscle activity
response to thyroid hormone
protein transmembrane import into intracellular organelle
tRNA transport
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
response to activity
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
response to amino acid
mitochondrial membrane organization
unfolded protein binding
protein import
macroautophagy
mitochondrial outer membrane
RNA transport
nucleic acid transport
establishment of RNA localization
mitochondrial transport
RNA localization
nucleobase-containing compound transport
autophagy
process utilizing autophagic mechanism
protein deubiquitination
protein modification by small protein removal
response to acid chemical