NDUFS8
Gene Information
- Official Symbol: NDUFS8
- Official Name: N/ADH:ubiquinone oxidoreductase core subunit S8
- Aliases and Previous Symbols: N/A
- Entrez ID: 4728
- UniProt: O00217
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010].
- UniProt Summary: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1018
- Expression level (log2 read counts): 5.62
NDUFS8 Expression in NALM6 Cells: 5.62
