MCAT [The Human Chemical-Genetic Interaction Map Project]

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======= MCAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCAT
  * **<color #00a2e8>Official Name</color>**: malonyl-CoA-acyl carrier protein transacylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27349|27349]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IVS2|Q8IVS2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. {ECO:0000269|PubMed:12882974}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyl transf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty acid synthase activity|
|[acyl-carrier-protein] S-malonyltransferase activity|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|monocarboxylic acid catabolic process|
|fatty acid biosynthetic process|
|monocarboxylic acid biosynthetic process|
|cellular lipid catabolic process|
|lipid modification|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|mitochondrion|
|RNA binding|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.7|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.88|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.98|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mto1|MTO1]]|0.57|
|[[:human genes:i:iba57|IBA57]]|0.57|
|[[:human genes:s:sfxn4|SFXN4]]|0.558|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.556|
|[[:human genes:a:acad9|ACAD9]]|0.556|
|[[:human genes:g:grsf1|GRSF1]]|0.545|
|[[:human genes:p:pet117|PET117]]|0.538|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.534|
|[[:human genes:c:c12orf65|C12orf65]]|0.532|
|[[:human genes:g:gfm2|GFM2]]|0.53|
|[[:human genes:c:coa6|COA6]]|0.53|
|[[:human genes:f:fastkd2|FASTKD2]]|0.529|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.529|
|[[:human genes:r:rpusd3|RPUSD3]]|0.529|
|[[:human genes:e:ecsit|ECSIT]]|0.526|
|[[:human genes:n:ndufb11|NDUFB11]]|0.524|
|[[:human genes:q:qrsl1|QRSL1]]|0.52|
|[[:human genes:m:mipep|MIPEP]]|0.516|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.516|
|[[:human genes:y:ybey|YBEY]]|0.515|
|[[:human genes:n:nsun4|NSUN4]]|0.507|
|[[:human genes:p:pet112|PET112]]|0.504|
|[[:human genes:e:ears2|EARS2]]|0.503|
|[[:human genes:n:ndufa3|NDUFA3]]|0.501|
|[[:human genes:l:lars2|LARS2]]|0.501|
|[[:human genes:m:malsu1|MALSU1]]|0.5|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.496|
|[[:human genes:g:glrx5|GLRX5]]|0.494|
|[[:human genes:r:rpusd4|RPUSD4]]|0.492|
|[[:human genes:a:aars2|AARS2]]|0.489|
|[[:human genes:m:mrps5|MRPS5]]|0.488|
|[[:human genes:m:mtif2|MTIF2]]|0.485|
|[[:human genes:m:mtg1|MTG1]]|0.485|
|[[:human genes:n:nubpl|NUBPL]]|0.485|
|[[:human genes:n:ndufa2|NDUFA2]]|0.483|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.48|
|[[:human genes:c:coa3|COA3]]|0.48|
|[[:human genes:p:pars2|PARS2]]|0.479|
|[[:human genes:e:eral1|ERAL1]]|0.474|
|[[:human genes:m:mrps16|MRPS16]]|0.474|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.471|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.468|
|[[:human genes:g:gfm1|GFM1]]|0.468|
|[[:human genes:m:mrpl23|MRPL23]]|0.466|
|[[:human genes:f:ftsj2|FTSJ2]]|0.465|
|[[:human genes:n:ndufa1|NDUFA1]]|0.464|
|[[:human genes:m:mrpl22|MRPL22]]|0.463|
|[[:human genes:m:mrps22|MRPS22]]|0.463|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.462|
|[[:human genes:m:mettl17|METTL17]]|0.459|
|[[:human genes:m:mrps34|MRPS34]]|0.459|
|[[:human genes:n:ndufb9|NDUFB9]]|0.458|
|[[:human genes:s:selrc1|SELRC1]]|0.457|
|[[:human genes:p:pde12|PDE12]]|0.457|
|[[:human genes:n:nars2|NARS2]]|0.457|
|[[:human genes:y:yars2|YARS2]]|0.454|
|[[:human genes:s:ssbp1|SSBP1]]|0.454|
|[[:human genes:n:ndufa8|NDUFA8]]|0.454|
|[[:human genes:c:chchd1|CHCHD1]]|0.452|
|[[:human genes:m:mrpl1|MRPL1]]|0.452|
|[[:human genes:m:mrps21|MRPS21]]|0.451|
|[[:human genes:a:ak3|AK3]]|0.45|
|[[:human genes:t:tsfm|TSFM]]|0.449|
|[[:human genes:c:coq2|COQ2]]|0.448|
|[[:human genes:n:ndufs2|NDUFS2]]|0.443|
|[[:human genes:n:ndufa10|NDUFA10]]|0.443|
|[[:human genes:f:fastkd5|FASTKD5]]|0.443|
|[[:human genes:p:polg|POLG]]|0.442|
|[[:human genes:c:cars2|CARS2]]|0.442|
|[[:human genes:r:rbfa|RBFA]]|0.442|
|[[:human genes:n:ndufb6|NDUFB6]]|0.441|
|[[:human genes:m:mrpl43|MRPL43]]|0.441|
|[[:human genes:c:cox11|COX11]]|0.441|
|[[:human genes:a:atp5sl|ATP5SL]]|0.44|
|[[:human genes:t:tmem261|TMEM261]]|0.44|
|[[:human genes:n:ndufb10|NDUFB10]]|0.44|
|[[:human genes:n:ndufv2|NDUFV2]]|0.439|
|[[:human genes:c:c17orf89|C17orf89]]|0.439|
|[[:human genes:m:mrps26|MRPS26]]|0.437|
|[[:human genes:f:foxred1|FOXRED1]]|0.437|
|[[:human genes:n:ndufb5|NDUFB5]]|0.437|
|[[:human genes:m:mrps35|MRPS35]]|0.432|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.432|
|[[:human genes:r:rars2|RARS2]]|0.431|
|[[:human genes:c:coq7|COQ7]]|0.431|
|[[:human genes:i:ict1|ICT1]]|0.429|
|[[:human genes:m:mrps6|MRPS6]]|0.428|
|[[:human genes:n:nfu1|NFU1]]|0.428|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.427|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.426|
|[[:human genes:r:rmnd1|RMND1]]|0.426|
|[[:human genes:m:mrpl18|MRPL18]]|0.426|
|[[:human genes:p:prim1|PRIM1]]|0.425|
|[[:human genes:p:pitrm1|PITRM1]]|0.424|
|[[:human genes:m:mrps27|MRPS27]]|0.424|
|[[:human genes:m:mrps18b|MRPS18B]]|0.422|
|[[:human genes:v:vars2|VARS2]]|0.422|
|[[:human genes:m:mrps12|MRPS12]]|0.421|
|[[:human genes:t:tars2|TARS2]]|0.42|
|[[:human genes:m:mterfd1|MTERFD1]]|0.42|
|[[:human genes:d:dap3|DAP3]]|0.419|
|[[:human genes:m:mrps25|MRPS25]]|0.419|
|[[:human genes:t:tfb1m|TFB1M]]|0.417|
|[[:human genes:m:mrpl21|MRPL21]]|0.416|
|[[:human genes:p:prepl|PREPL]]|0.415|
|[[:human genes:t:tpk1|TPK1]]|0.415|
|[[:human genes:m:mtg2|MTG2]]|0.414|
|[[:human genes:p:pdss2|PDSS2]]|0.414|
|[[:human genes:t:tomm20|TOMM20]]|0.414|
|[[:human genes:m:mrps10|MRPS10]]|0.414|
|[[:human genes:n:ndufb7|NDUFB7]]|0.412|
|[[:human genes:d:ddx28|DDX28]]|0.412|
|[[:human genes:m:mrpl47|MRPL47]]|0.411|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.411|
|[[:human genes:n:ndufb2|NDUFB2]]|0.411|
|[[:human genes:w:wars2|WARS2]]|0.41|
|[[:human genes:m:mrpl45|MRPL45]]|0.41|
|[[:human genes:p:polg2|POLG2]]|0.408|
|[[:human genes:m:mrpl55|MRPL55]]|0.408|
|[[:human genes:g:got2|GOT2]]|0.408|
|[[:human genes:p:ptcd3|PTCD3]]|0.407|
|[[:human genes:m:mrpl53|MRPL53]]|0.406|
|[[:human genes:c:coq3|COQ3]]|0.405|
|[[:human genes:m:mrpl49|MRPL49]]|0.405|
|[[:human genes:t:timm8b|TIMM8B]]|0.404|
|[[:human genes:m:mrpl4|MRPL4]]|0.403|
|[[:human genes:p:polrmt|POLRMT]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1682
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCAT Expression in NALM6 Cells: 3.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>