AASDHPPT [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= AASDHPPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AASDHPPT
  * **<color #00a2e8>Official Name</color>**: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60496|60496]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRN7|Q9NRN7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AASDHPPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AASDHPPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607756|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ACPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|holo-[acyl-carrier-protein] synthase activity|
|lysine biosynthetic process|
|lysine biosynthetic process via aminoadipic acid|
|pantothenate metabolic process|
|lysine metabolic process|
|aspartate family amino acid biosynthetic process|
|aspartate family amino acid metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|water-soluble vitamin metabolic process|
|vitamin metabolic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|magnesium ion binding|
|coenzyme metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|cofactor metabolic process|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.61|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.06|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.88|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.84|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.81|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.81|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.8|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.8|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.81|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.81|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.81|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.82|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.88|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.98|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.99|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.22|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.22|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.39|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.41|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.45|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.61|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|3.01|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc25a26|SLC25A26]]|0.738|
|[[:human genes:n:nfu1|NFU1]]|0.647|
|[[:human genes:t:tpk1|TPK1]]|0.629|
|[[:human genes:i:iba57|IBA57]]|0.583|
|[[:human genes:g:glrx5|GLRX5]]|0.577|
|[[:human genes:p:pmm2|PMM2]]|0.576|
|[[:human genes:t:triap1|TRIAP1]]|0.576|
|[[:human genes:b:bcs1l|BCS1L]]|0.574|
|[[:human genes:i:isca2|ISCA2]]|0.573|
|[[:human genes:r:rpe|RPE]]|0.571|
|[[:human genes:a:atic|ATIC]]|0.567|
|[[:human genes:s:slc25a19|SLC25A19]]|0.555|
|[[:human genes:t:thg1l|THG1L]]|0.555|
|[[:human genes:a:atxn10|ATXN10]]|0.552|
|[[:human genes:m:mrpl21|MRPL21]]|0.545|
|[[:human genes:d:dpagt1|DPAGT1]]|0.542|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.54|
|[[:human genes:r:rpia|RPIA]]|0.536|
|[[:human genes:a:alg1|ALG1]]|0.535|
|[[:human genes:s:srp14|SRP14]]|0.531|
|[[:human genes:m:mrps5|MRPS5]]|0.53|
|[[:human genes:l:lsm10|LSM10]]|0.53|
|[[:human genes:v:vezt|VEZT]]|0.528|
|[[:human genes:s:sucla2|SUCLA2]]|0.521|
|[[:human genes:t:tkt|TKT]]|0.519|
|[[:human genes:g:gfm2|GFM2]]|0.517|
|[[:human genes:c:c17orf89|C17orf89]]|0.516|
|[[:human genes:p:pdss1|PDSS1]]|0.516|
|[[:human genes:f:fh|FH]]|0.515|
|[[:human genes:c:c12orf65|C12orf65]]|0.513|
|[[:human genes:c:cox16|COX16]]|0.511|
|[[:human genes:m:mrpl23|MRPL23]]|0.509|
|[[:human genes:r:rpusd4|RPUSD4]]|0.509|
|[[:human genes:c:chchd4|CHCHD4]]|0.505|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.495|
|[[:human genes:d:dars2|DARS2]]|0.493|
|[[:human genes:r:romo1|ROMO1]]|0.493|
|[[:human genes:p:ppcs|PPCS]]|0.492|
|[[:human genes:d:dnlz|DNLZ]]|0.489|
|[[:human genes:a:alg13|ALG13]]|0.488|
|[[:human genes:m:mrps34|MRPS34]]|0.488|
|[[:human genes:g:gemin8|GEMIN8]]|0.486|
|[[:human genes:m:mrps33|MRPS33]]|0.485|
|[[:human genes:c:crls1|CRLS1]]|0.482|
|[[:human genes:m:mrps2|MRPS2]]|0.481|
|[[:human genes:t:tmem242|TMEM242]]|0.481|
|[[:human genes:r:rfk|RFK]]|0.48|
|[[:human genes:e:eno1|ENO1]]|0.478|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.477|
|[[:human genes:f:fdxr|FDXR]]|0.475|
|[[:human genes:l:lonp1|LONP1]]|0.475|
|[[:human genes:y:yars2|YARS2]]|0.471|
|[[:human genes:t:tufm|TUFM]]|0.47|
|[[:human genes:m:mrps18a|MRPS18A]]|0.47|
|[[:human genes:d:dohh|DOHH]]|0.467|
|[[:human genes:m:mrps16|MRPS16]]|0.467|
|[[:human genes:s:sars2|SARS2]]|0.464|
|[[:human genes:g:gemin6|GEMIN6]]|0.464|
|[[:human genes:r:rbfa|RBFA]]|0.463|
|[[:human genes:m:mrp63|MRP63]]|0.463|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.463|
|[[:human genes:m:mrpl15|MRPL15]]|0.463|
|[[:human genes:n:ndufa3|NDUFA3]]|0.462|
|[[:human genes:g:gemin7|GEMIN7]]|0.461|
|[[:human genes:s:sco2|SCO2]]|0.461|
|[[:human genes:m:mrps14|MRPS14]]|0.461|
|[[:human genes:t:taz|TAZ]]|0.46|
|[[:human genes:u:uhrf1|UHRF1]]|0.459|
|[[:human genes:m:mrpl27|MRPL27]]|0.459|
|[[:human genes:d:dap3|DAP3]]|0.458|
|[[:human genes:c:coq5|COQ5]]|0.455|
|[[:human genes:r:rbmx2|RBMX2]]|0.454|
|[[:human genes:g:gfm1|GFM1]]|0.452|
|[[:human genes:w:wbscr16|WBSCR16]]|0.451|
|[[:human genes:n:ndufb5|NDUFB5]]|0.45|
|[[:human genes:a:abhd11|ABHD11]]|0.45|
|[[:human genes:m:mrps26|MRPS26]]|0.449|
|[[:human genes:m:mrpl47|MRPL47]]|0.449|
|[[:human genes:h:haus8|HAUS8]]|0.449|
|[[:human genes:t:tpi1|TPI1]]|0.449|
|[[:human genes:p:pgm3|PGM3]]|0.447|
|[[:human genes:t:trmt61a|TRMT61A]]|0.446|
|[[:human genes:d:dhrsx|DHRSX]]|0.444|
|[[:human genes:z:zrsr2|ZRSR2]]|0.444|
|[[:human genes:a:adsl|ADSL]]|0.444|
|[[:human genes:f:fars2|FARS2]]|0.444|
|[[:human genes:m:mrpl53|MRPL53]]|0.443|
|[[:human genes:s:srd5a3|SRD5A3]]|0.443|
|[[:human genes:k:kctd5|KCTD5]]|0.441|
|[[:human genes:m:mrps36|MRPS36]]|0.438|
|[[:human genes:c:coq2|COQ2]]|0.438|
|[[:human genes:h:hccs|HCCS]]|0.437|
|[[:human genes:n:n6amt1|N6AMT1]]|0.437|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.436|
|[[:human genes:t:tamm41|TAMM41]]|0.436|
|[[:human genes:n:ndufb3|NDUFB3]]|0.434|
|[[:human genes:p:ppp6c|PPP6C]]|0.434|
|[[:human genes:m:mtpap|MTPAP]]|0.432|
|[[:human genes:m:mrps21|MRPS21]]|0.43|
|[[:human genes:p:pgp|PGP]]|0.43|
|[[:human genes:e:ears2|EARS2]]|0.43|
|[[:human genes:m:mrps6|MRPS6]]|0.429|
|[[:human genes:r:rft1|RFT1]]|0.429|
|[[:human genes:t:trmt5|TRMT5]]|0.429|
|[[:human genes:p:pgk1|PGK1]]|0.428|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.427|
|[[:human genes:n:ndufb6|NDUFB6]]|0.427|
|[[:human genes:u:utp23|UTP23]]|0.426|
|[[:human genes:z:zcrb1|ZCRB1]]|0.426|
|[[:human genes:m:mcat|MCAT]]|0.426|
|[[:human genes:n:ndufb11|NDUFB11]]|0.425|
|[[:human genes:p:ppa2|PPA2]]|0.424|
|[[:human genes:g:gmppb|GMPPB]]|0.423|
|[[:human genes:n:nbn|NBN]]|0.423|
|[[:human genes:d:dhx30|DHX30]]|0.422|
|[[:human genes:f:fastkd5|FASTKD5]]|0.422|
|[[:human genes:u:uba3|UBA3]]|0.42|
|[[:human genes:m:mrps11|MRPS11]]|0.419|
|[[:human genes:m:mipep|MIPEP]]|0.419|
|[[:human genes:a:atp5sl|ATP5SL]]|0.419|
|[[:human genes:g:gfpt1|GFPT1]]|0.417|
|[[:human genes:c:c15orf41|C15orf41]]|0.417|
|[[:human genes:c:cep57|CEP57]]|0.416|
|[[:human genes:u:uap1|UAP1]]|0.415|
|[[:human genes:t:trmt10a|TRMT10A]]|0.415|
|[[:human genes:s:sod2|SOD2]]|0.415|
|[[:human genes:c:cox6c|COX6C]]|0.414|
|[[:human genes:c:cbx3|CBX3]]|0.414|
|[[:human genes:e:elac2|ELAC2]]|0.413|
|[[:human genes:t:tbca|TBCA]]|0.413|
|[[:human genes:m:mrps23|MRPS23]]|0.413|
|[[:human genes:m:mrps9|MRPS9]]|0.412|
|[[:human genes:l:lipt2|LIPT2]]|0.412|
|[[:human genes:c:coq3|COQ3]]|0.411|
|[[:human genes:h:hars|HARS]]|0.411|
|[[:human genes:p:ppcdc|PPCDC]]|0.411|
|[[:human genes:r:rtcb|RTCB]]|0.411|
|[[:human genes:u:uqcr10|UQCR10]]|0.408|
|[[:human genes:d:dhps|DHPS]]|0.407|
|[[:human genes:m:med16|MED16]]|0.407|
|[[:human genes:m:mrpl36|MRPL36]]|0.407|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.406|
|[[:human genes:t:trnt1|TRNT1]]|0.405|
|[[:human genes:d:dr1|DR1]]|0.404|
|[[:human genes:t:ten1|TEN1]]|0.403|
|[[:human genes:p:polg|POLG]]|0.403|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.403|
|[[:human genes:c:cox17|COX17]]|0.402|
|[[:human genes:g:gatc|GATC]]|0.401|
|[[:human genes:s:selrc1|SELRC1]]|0.401|
|[[:human genes:p:pdk3|PDK3]]|0.401|
|[[:human genes:m:mrpl20|MRPL20]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AASDHPPT Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>